US 12,221,475 B2
Chimeric antigen receptor and application thereof
Wen Hu, Guangdong (CN); Yongchao Yao, Guangdong (CN); Wenzhong Guo, Guangdong (CN); Yinbo Jiang, Guangdong (CN); Shuozhou Huang, Guangdong (CN); Ting Jiang, Guangdong (CN); Jiaojiao Li, Guangdong (CN); Zhu Tao, Guangdong (CN); Yanli Gu, Guangdong (CN); Huihui Zhang, Guangdong (CN); Li Qin, Guangdong (CN); and Xiaoping Chen, Guangdong (CN)
Assigned to CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd., Guangzhou (CN)
Appl. No. 17/051,747
Filed by CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd., Guangzhou (CN)
PCT Filed Nov. 29, 2017, PCT No. PCT/CN2017/113661
§ 371(c)(1), (2) Date Oct. 29, 2020,
PCT Pub. No. WO2019/104562, PCT Pub. Date Jun. 6, 2019.
Prior Publication US 2021/0221880 A1, Jul. 22, 2021
Int. Cl. C07K 16/20 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01)
CPC C07K 16/205 (2013.01) [A61K 39/00 (2013.01); A61K 39/0011 (2013.01); A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/4647 (2023.05); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C12N 5/0636 (2013.01); A61K 38/00 (2013.01); A61K 2239/13 (2023.05); A61K 2239/24 (2023.05); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/22 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C07K 2319/43 (2013.01)] 8 Claims
 
1. A chimeric antigen receptor, wherein the chimeric antigen receptor contains an antigen recognition domain,
wherein the antigen recognition domain is a domain which recognizes a malarial protein VAR2CSA or a recombinant protein comprising any one or at least two placental-like chondroitin sulfate A-binding domains of the malarial protein VAR2CSA,
wherein the antigen recognition domain contains a variable heavy chain and a variable light chain,
wherein
the variable heavy chain comprises:
CDR1 having an amino acid sequence as shown in SEQ ID NO. 13;
CDR2 having an amino acid sequence as shown in SEQ ID NO. 14; and
CDR3 having an amino acid sequence as shown in SEQ ID NO. 15;
and
the variable light chain comprises:
CDR1 having an amino acid sequence as shown in SEQ ID NO. 16;
CDR2 having an amino acid sequence as shown in SEQ ID NO. 17; and
CDR3 having an amino acid sequence as shown in SEQ ID NO. 18.