	US 12,221,470 B2
	Yeast-fermented recombinant fibronectin peptide in small molecule, and its preparation method and applications thereof
Renquan Ruan, Guangdong (CN); and Longping Wen, Guangdong (CN)
Assigned to MELLGEN (SHENZHEN) BIOTECHNOLOGY CO., LTD., Shenzhen (CN)
Appl. No. 17/606,699
Filed by MELLGEN (SHENZHEN) BIOTECHNOLOGY CO., LTD., Guangdong (CN)
PCT Filed Feb. 24, 2020, PCT No. PCT/CN2020/076337 § 371(c)(1), (2) Date Oct. 26, 2021, PCT Pub. No. WO2020/228390, PCT Pub. Date Nov. 19, 2020.
Claims priority of application No. 201910388775.3 (CN), filed on May 10, 2019.
Prior Publication US 2022/0220190 A1, Jul. 14, 2022
Int. Cl. A61K 8/64 (2006.01); A61K 9/00 (2006.01); A61K 38/39 (2006.01); A61K 38/46 (2006.01); A61Q 19/00 (2006.01); C07K 14/39 (2006.01); C07K 14/78 (2006.01); C07K 19/00 (2006.01); C12N 9/00 (2006.01); C12N 15/81 (2006.01); A61K 38/00 (2006.01)

CPC C07K 14/78 (2013.01) [A61K 8/64 (2013.01); A61K 9/0014 (2013.01); A61K 38/39 (2013.01); A61K 38/46 (2013.01); A61Q 19/00 (2013.01); C07K 14/39 (2013.01); C12N 9/00 (2013.01); C12N 15/815 (2013.01); A61K 38/00 (2013.01); A61K 2800/85 (2013.01); C07K 2319/00 (2013.01)]

8 Claims

1. A recombinant fibronectin peptide, comprising sequentially-connected amino acid sequences of:

a β subunit binding domain of sodium-potassium-ATPase, wherein the amino acid sequence of the β subunit binding domain of sodium-potassium-ATPase is shown in SEQ ID NO: 2;

a fibrin binding domain, wherein the amino acid sequence of the fibrin binding domain is shown in SEQ ID NO: 3;

a collagen binding domain, wherein the amino acid sequence of the collagen binding domain is shown in SEQ ID NO: 4;

a heparin-binding domain, wherein the amino acid sequence of the heparin-binding domain is shown in SEQ ID NO: 5; and

a domain of fibronectin, wherein the domain of fibronectin includes an integrin binding domain of fibronectin as shown in SEQ ID NO: 6.