	US 12,221,463 B2
	Method of promoting wound healing by inhibiting CCR3
Randle M. Gallucci, Edmond, OK (US); and Kaitlin N. Calhoun, Greeley, CO (US)
Assigned to The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed by The Board of Regents of the University of Oklahoma, Norman, OK (US)
Filed on Aug. 6, 2021, as Appl. No. 17/396,235.
Claims priority of provisional application 63/062,535, filed on Aug. 7, 2020.
Prior Publication US 2022/0041668 A1, Feb. 10, 2022
Int. Cl. A61K 39/395 (2006.01); A61P 17/02 (2006.01); C07K 14/47 (2006.01); C07K 16/00 (2006.01); C07K 16/24 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)

CPC C07K 14/4703 (2013.01) [A61K 39/395 (2013.01); A61P 17/02 (2018.01); C07K 16/00 (2013.01); C07K 16/24 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01)]

10 Claims

1. A method of treating a skin wound in a subject, comprising:

administering to the subject at least one inhibitor selected from the group consisting of a neutralizing anti-C-C chemokine receptor type-3 (CCR3) antibody and a neutralizing anti-CCR3 fragment thereof, thereby causing increased activity of keratinocytes adjacent the skin wound, wherein epithelialization of the skin wound is increased, and wherein the increased activity of keratinocytes is at least one of (1) increased proliferation of the keratinocytes and (2) increased migration of the keratinocytes adjacent the skin wound.