US 12,221,457 B2
Boron-containing compound and method for producing same
Masafumi Hirano, Fuchu (JP); Nobuyuki Komine, Fuchu (JP); Sayori Kiyota, Fuchu (JP); and Keita Shimada, Fuchu (JP)
Assigned to NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY, Tokyo (JP)
Appl. No. 17/429,103
Filed by National University Corporation Tokyo University of Agriculture and Technology, Fuchu (JP)
PCT Filed Feb. 6, 2020, PCT No. PCT/JP2020/004682
§ 371(c)(1), (2) Date Aug. 6, 2021,
PCT Pub. No. WO2020/162575, PCT Pub. Date Aug. 13, 2020.
Claims priority of application No. 2019-021791 (JP), filed on Feb. 8, 2019.
Prior Publication US 2022/0135596 A1, May 5, 2022
Int. Cl. C07F 5/02 (2006.01); B01J 23/46 (2006.01)
CPC C07F 5/025 (2013.01) [B01J 23/462 (2013.01)] 11 Claims
 
1. A method for producing a boron-containing compound, comprising:
a step of reacting a first raw material compound represented by the following formula (I-1):

OG Complex Work Unit Chemistry
with a second raw material compound represented by the following formula (II-1):

OG Complex Work Unit Chemistry
in the presence of a ruthenium catalyst to obtain a boron-containing compound represented by the following formula (III-1):

OG Complex Work Unit Chemistry
wherein RA1, RA2, RA3, RB1, RB2, RB3, RB4, RB5 and RB6 each independently represent a hydrogen atom or a monovalent group, provided that at least one of RA1, RB1, RB2, RB3, RB4, RB5 and RB6 is a boron-containing group that binds to a binding target through a boron atom.
 
6. A boron-containing compound represented by the following formula (III-1):

OG Complex Work Unit Chemistry
wherein RA1 represents a monovalent group,
RA2, RA3, RB1, RB2, RB3, RB4, RB5 and RB6 each independently represent a hydrogen atom or a monovalent group,
provided that at least one of RA1 and RB1 is a boron-containing group that binds to a binding target through a boron atom,
wherein one of RB5 and RB6 is a hydrogen atom, and the other is a monovalent organic group or a halogeno group.