US 12,221,450 B1
5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues as antibacterial agents
Katharigatta N. Venugopala, Al-Ahsa (SA); Pran Kishore Deb, Ranchi (IN); Vinuta Kamat, Mangalagangothri (IN); Rangappa Santosh, Mangalagangothri (IN); Boja Poojary, Mangalagangothri (IN); Manohar S. Kugaji, Belagavi (IN); Vijay M. Kumbar, Belagavi (IN); Mohamed A. Morsy, Al-Ahsa (SA); Bandar Aldhubiab, Al-Ahsa (SA); Mahesh Attimarad, Al-Ahsa (SA); Anroop B. Nair, Al-Ahsa (SA); and Nagaraja Sreeharsha, Al-Ahsa (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Mar. 27, 2024, as Appl. No. 18/618,824.
Application 18/618,824 is a continuation of application No. 18/232,012, filed on Aug. 9, 2023.
Int. Cl. C07D 487/04 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01); C07D 471/04 (2006.01)
CPC C07D 487/04 (2013.01) [A61P 31/04 (2018.01); A61P 31/10 (2018.01); C07D 471/04 (2013.01)] 14 Claims
 
1. A compound having the formula 4:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R1 is selected from the group consisting of hydrogen, hydroxy, and benzyloxy;
R2 is selected from the group consisting of hydrogen, a C1-C6 straight or branched chain alkoxy, and benzyloxy;
R3 is selected from the group consisting of hydrogen and a C1-C6 straight or branched chain alkyl; and
R4 is selected from the group consisting of hydrogen and a C1-C6 straight or branched chain alkyl;
wherein R1 and R2 are not both H.