US 12,221,446 B2
Crystalline salt of 5-methyl-(6S)-tetrahydrofolic acid and L-isoleucine ethyl ester
Rudolf Moser, Schaffhausen (CH); Viola Groehn, Dachsen (CH); Ruth Boehni Stamm, Stein Am Rhein (CH); Fritz Blatter, Reinach (CH); and Martin Szelagiewicz, Basel (CH)
Appl. No. 17/258,257
Filed by Merck Patent GmbH, Darmstadt (DE)
PCT Filed Jul. 2, 2019, PCT No. PCT/EP2019/067694
§ 371(c)(1), (2) Date Jan. 6, 2021,
PCT Pub. No. WO2020/007836, PCT Pub. Date Jan. 9, 2020.
Claims priority of application No. 18182278 (EP), filed on Jul. 6, 2018.
Prior Publication US 2021/0269444 A1, Sep. 2, 2021
Int. Cl. C07D 475/04 (2006.01); C07C 229/08 (2006.01)
CPC C07D 475/04 (2013.01) [C07C 229/08 (2013.01); C07B 2200/13 (2013.01)] 26 Claims
 
1. A crystalline salt of 5-methyl-(6S)-tetrahydrofolic acid and L-isoleucine ethyl ester wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to L-isoleucine ethyl ester is from 1:0.3 to 1:2.0 (in mol/mol) and/or hydrates and/or solvates thereof.