US 12,221,445 B2
Crystalline salts of 5-methyl-(6S)-tetrahydrofolic acid and amino ethyl esters
Rudolf Moser, Schaffhausen (CH); Viola Groehn, Dachsen (CH); Ruth Boehni Stamm, Stein Am Rhein (CH); Fritz Blatter, Reinach (CH); and Martin Szelagiewicz, Basel (CH)
Assigned to MERCK PATENT GMBH, Darmstadt (DE)
Appl. No. 17/258,040
Filed by MERCK PATENT GMBH, Darmstadt (DE)
PCT Filed Jul. 2, 2019, PCT No. PCT/EP2019/067705
§ 371(c)(1), (2) Date Jan. 5, 2021,
PCT Pub. No. WO2020/007843, PCT Pub. Date Jan. 9, 2020.
Claims priority of application No. 18182284 (EP), filed on Jul. 6, 2018; and application No. 19168723 (EP), filed on Apr. 11, 2019.
Prior Publication US 2021/0277006 A1, Sep. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 475/04 (2006.01); A61K 45/06 (2006.01); C07C 229/36 (2006.01)
CPC C07D 475/04 (2013.01) [A61K 45/06 (2013.01); C07C 229/36 (2013.01); C07B 2200/13 (2013.01)] 37 Claims
OG exemplary drawing
 
1. A crystalline salt comprising 5-methyl-(6S)-tetrahydrofolic acid and an amino acid ethyl ester wherein the molar ratio of 5-methyl-(6S)-tetrahydrofolic acid to amino acid ethyl ester is from 1:0.3 to 1:3.0 (in mol/mol) and/or hydrates and/or solvates thereof.