US 12,221,440 B2
Process for the preparation of trametinib acetic acid solvate
Gangadhara Bhima Shankar Nangi, Hyderabad (IN); Ramadas Chavakula, Hyderabad (IN); Venkata Rama Krishna Murthy Moturu, Hyderabad (IN); Jyothi Sudharshan Chakradhar Saladi, Hyderabad (IN); Sandeep Kumar Vadla, Hyderabad (IN); Sadashiv Jagtap, Hyderabad (IN); and Sivakumaran Meenakshisunderam, Hyderabad (IN)
Assigned to Aurobindo Pharma Ltd, Hyderabad (IN)
Appl. No. 17/427,633
Filed by Aurobindo Pharma Ltd., Hyderabad (IN)
PCT Filed Feb. 6, 2020, PCT No. PCT/IB2020/050942
§ 371(c)(1), (2) Date Jul. 31, 2021,
PCT Pub. No. WO2020/061654, PCT Pub. Date Aug. 13, 2020.
Claims priority of application No. 201941004635 (IN), filed on Feb. 6, 2019.
Prior Publication US 2022/0098192 A1, Mar. 31, 2022
Int. Cl. C07D 471/04 (2006.01); A61K 31/519 (2006.01)
CPC C07D 471/04 (2013.01) [C07B 2200/13 (2013.01)] 7 Claims
 
1. Crystalline Form of Trametinib acetic acid solvate (Ia), characterized by

OG Complex Work Unit Chemistry
with X-ray diffraction pattern, having characteristic peaks at 5.2, 10.4, 12.8, 20.9, 22.1, 24.6 and 27.8±0.2 angle 2θ.