US 12,221,411 B2
Processes and intermediates for the preparation of carbaprostacyclin analogues
Chun-Yu Lin, Yangmei (TW); Tzyh-Mann Wei, Yangmei (TW); and Shih-Yi Wei, Yangmei (TW)
Assigned to CHIROGATE INTERNATIONAL INC., Yangmei (TW)
Filed by CHIROGATE INTERNATIONAL INC., Yangmei (TW)
Filed on May 30, 2023, as Appl. No. 18/325,214.
Application 18/325,214 is a division of application No. 17/737,273, filed on May 5, 2022, granted, now 11,884,613.
Prior Publication US 2023/0357119 A1, Nov. 9, 2023
Int. Cl. C07C 33/12 (2006.01); C07C 49/743 (2006.01); C07C 59/62 (2006.01); C07D 307/42 (2006.01); C12P 7/38 (2006.01); C12P 7/62 (2022.01)
CPC C07C 49/743 (2013.01) [C07C 33/12 (2013.01); C07C 59/62 (2013.01); C07D 307/42 (2013.01); C12P 7/38 (2013.01); C12P 7/62 (2013.01)] 17 Claims
 
1. A racemic or optically active compound of Formula 1:

OG Complex Work Unit Chemistry
wherein Y is —CH2OP or —COOR1; X is F, Cl, Br, I, or —OTs; P is H or a hydroxyl protective group; and R1 is C1-7-alkyl, aryl or aralkyl, each of which is unsubstituted or substituted by C1-4-alkyl, C2-7-alkenyl, C2-7-alkynyl, nitro, halogen or alkoxy.