US 12,221,406 B2
Compounds as NLRP3 inflammasome inhibitors and compositions and uses thereof
Shijun Zhang, Glen Allen, VA (US)
Assigned to Virginia Commonwealth University, Richmond, VA (US)
Appl. No. 17/627,214
Filed by VIRGINIA COMMONWEALTH UNIVERSITY, Richmond, VA (US)
PCT Filed Jul. 15, 2020, PCT No. PCT/US2020/042036
§ 371(c)(1), (2) Date Jan. 14, 2022,
PCT Pub. No. WO2021/011592, PCT Pub. Date Jan. 21, 2021.
Claims priority of provisional application 62/874,570, filed on Jul. 16, 2019.
Prior Publication US 2022/0259144 A1, Aug. 18, 2022
Int. Cl. C07D 333/24 (2006.01); A61P 37/02 (2006.01); C07C 311/37 (2006.01); C07C 311/46 (2006.01); C07D 207/20 (2006.01); C07D 209/14 (2006.01); C07D 233/26 (2006.01); C07D 241/12 (2006.01); C07D 249/04 (2006.01); C07D 277/56 (2006.01); C07D 277/593 (2006.01); C07D 285/06 (2006.01); C07D 307/64 (2006.01); C07D 317/62 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01)
CPC C07C 311/37 (2013.01) [A61P 37/02 (2018.01); C07C 311/46 (2013.01); C07D 207/20 (2013.01); C07D 209/14 (2013.01); C07D 233/26 (2013.01); C07D 241/12 (2013.01); C07D 249/04 (2013.01); C07D 277/56 (2013.01); C07D 277/593 (2013.01); C07D 285/06 (2013.01); C07D 307/64 (2013.01); C07D 317/62 (2013.01); C07D 333/24 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01)] 1 Claim
 
1. A compound having the chemical structure of

OG Complex Work Unit Chemistry
and pharmaceutically acceptable salts, solvates, or hydrates thereof.