US 12,220,685 B2
Solid-phase extraction material, and preparation method and use thereof
Qing Zhou, Nanjing (CN); Ziang Zhang, Nanjing (CN); Junxia Chen, Nanjing (CN); Yurong Chen, Nanjing (CN); Chongtian Lei, Nanjing (CN); Ranqiu Wang, Nanjing (CN); Weiwei Zhou, Nanjing (CN); and Libin Zhang, Nanjing (CN)
Assigned to NANJING UNIVERSITY, Nanjing (CN)
Appl. No. 17/910,312
Filed by NANJING UNIVERSITY, Nanjing (CN)
PCT Filed May 6, 2022, PCT No. PCT/CN2022/091097
§ 371(c)(1), (2) Date Sep. 8, 2022,
PCT Pub. No. WO2023/082566, PCT Pub. Date May 19, 2023.
Claims priority of application No. 202111347253.2 (CN), filed on Nov. 15, 2021.
Prior Publication US 2024/0207815 A1, Jun. 27, 2024
Int. Cl. B01J 20/26 (2006.01); B01J 20/30 (2006.01); C02F 1/26 (2023.01)
CPC B01J 20/261 (2013.01) [B01J 20/3064 (2013.01); B01J 20/3071 (2013.01); B01J 20/3078 (2013.01); C02F 1/26 (2013.01); B01J 2220/445 (2013.01); B01J 2220/50 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method for preparing a solid-phase extraction material, comprising:
preparing an emulsion A of monodispersed seed microsphere;
performing prepolymerization reaction based on monomers N-vinylpyrrolidone and divinylbenzene in the presence of a chain transfer agent; and
adding a product of the prepolymerization reaction dropwise into the emulsion A of monodispersed seed microspheres to obtain a mixture, swelling the mixture and allowing it to react to form white spheres, and functionalizing the white spheres to obtain the solid-phase extraction material;
wherein performing the prepolymerization reaction comprises:
mixing the monomers N-vinylpyrrolidone and divinylbenzene, an emulsifier, a free radical initiator, and a chain transfer agent, and ultrasonically dispersing them in an aqueous phase to form an emulsion B; and
performing the prepolymerization reaction on the emulsion B at a temperature in a range of 45° C. to 55° C.,
wherein a molar ratio of the free radical initiator to the chain transfer agent is 1: (1-2.8), and
wherein the chain transfer agent is one or more of S,S′-bis(α,α′-dimethyl-α″-acetic acid) trithiocarbonate, S,S′-p-(α,α′-dimethyl-α″-acetic acid) trithiocarbonate, and S-1-dodecyl-S′ (α,α′-dimethyl-α″-acetic acid) trithiocarbonate.