	US 12,220,595 B2
	Stem cell rich plasma compositions and uses thereof for treating aging subjects
Dipnarine Maharaj, Boynton Beach, FL (US)
Assigned to Advanced Neuroregenerative Therapies, LLC., Boynton Beach, FL (US)
Filed by Advanced Neuroregenerative Therapies, LLC, Boynton Beach, FL (US)
Filed on Oct. 21, 2021, as Appl. No. 17/507,441.
Application 17/507,441 is a division of application No. 16/534,720, filed on Aug. 7, 2019, granted, now 11,173,318.
Application 16/534,720 is a continuation of application No. 14/889,756, abandoned, previously published as PCT/US2014/037496, filed on May 9, 2014.
Claims priority of provisional application 61/893,444, filed on Oct. 21, 2013.
Claims priority of provisional application 61/821,319, filed on May 9, 2013.
Prior Publication US 2022/0105354 A1, Apr. 7, 2022
Int. Cl. A61K 35/28 (2015.01); A61K 35/12 (2015.01); A61K 35/16 (2015.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61N 2/00 (2006.01); A61N 2/02 (2006.01)

CPC A61N 2/002 (2013.01) [A61K 35/12 (2013.01); A61K 35/16 (2013.01); A61K 35/28 (2013.01); A61K 38/18 (2013.01); A61K 38/193 (2013.01); A61N 2/02 (2013.01)]

19 Claims

1. A method of treating an aging subject comprising:

a) preparing an allogeneic stem cell rich plasma composition by administering to a young healthy donor a stem cell mobilization agent in an amount and for a time period sufficient to stimulate a significantly increased number of stem cells in the blood of the donor, wherein the stem cell mobilization agent is a granulocyte colony stimulating factor (G-CSF);

b) obtaining a sufficient volume of plasma by plasmapheresis from the donor blood by separating cellular material from the blood and retaining the stem cell rich plasma; and

c) administering the allogeneic stem cell rich plasma composition to the aging recipient who has the ABO/Rh blood type of said donor, wherein upon administration of the plasma to the aging recipient in need thereof, the plasma induces a change in at least one or a combination of biomarkers, thereby treating the aging subject.