US 12,220,515 B2
Modular extracorporeal ambulatory lung assist device
William J. Federspiel, Pittsburgh, PA (US); Shalv Madhani, Costa Mesa, CA (US); Ryan A. Orizondo, Pittsburgh, PA (US); Peter Drew Wearden, Orlando, FL (US); Brian Joseph Frankowski, Imperial, PA (US); Alexandra May, Miami, FL (US); and Gregory Burgreen, Starkville, MS (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US); and Mississippi State University, Starkville, MS (US)
Appl. No. 16/961,440
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US); and Mississippi State University, Starkville, MS (US)
PCT Filed Jan. 15, 2019, PCT No. PCT/US2019/013678
§ 371(c)(1), (2) Date Jul. 10, 2020,
PCT Pub. No. WO2019/143623, PCT Pub. Date Jul. 25, 2019.
Claims priority of provisional application 62/617,809, filed on Jan. 16, 2018.
Prior Publication US 2021/0077706 A1, Mar. 18, 2021
Prior Publication US 2022/0080095 A2, Mar. 17, 2022
Int. Cl. A61M 1/36 (2006.01); A61M 1/16 (2006.01); A61M 60/113 (2021.01); A61M 60/216 (2021.01); A61M 60/38 (2021.01); A61M 60/825 (2021.01)
CPC A61M 1/3667 (2014.02) [A61M 1/1625 (2014.02); A61M 1/1698 (2013.01); A61M 1/3623 (2022.05); A61M 60/113 (2021.01); A61M 60/216 (2021.01); A61M 60/38 (2021.01); A61M 60/825 (2021.01); A61M 2202/0225 (2013.01); A61M 2205/7536 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for lung assist, comprising:
a plurality of separate fiber bundle sections, each of the fiber bundle sections comprising a fiber bundle housing defining a fiber bundle compartment therein, a fiber bundle positioned within the fiber bundle compartment, the fiber bundle comprising a plurality of hollow gas permeable fibers, the plurality of hollow gas permeable fibers being adapted to permit diffusion of gas between blood and an interior of the plurality of hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment, the fiber bundle of each of the plurality of fiber bundle sections being different in at least one property from the fiber bundle of each of the other of the plurality of fiber bundle sections, each fiber bundle housing further comprising a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the fiber bundle housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, a blood outlet in fluid connection with a first end of the fiber bundle housing, and a first interface disposed on a second end of the fiber bundle housing opposite the first end, and
a base section comprising a housing comprising a pressurizing section including a pressurizing compartment and an interface section, the interface section including an extending section which is positioned at a lateral end of the pressurizing section and extends at an angle from the lateral end of the pressurizing section and a second interface formed on the extending section and configured to form a releasable, sealing connection with the first interface of one of the plurality of fiber bundle sections such that the fiber bundle housing of the one of the plurality of fiber bundle sections extends substantially parallel to the pressurizing section, wherein the base section housing and the fiber bundle housing are separate elements connected by the releasable, sealing connection between the first and second interfaces, the pressurizing section further including a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit in fluid connection with the pressurizing compartment at a first end thereof via which pressurized fluid exits the pressurizing compartment, wherein a second end of the conduit is placed in fluid connection with a second end of the fiber bundle when the fiber bundle housing of the fiber bundle section is connected to the housing of the base section via the first interface and the second interface.