	US 12,220,499 B2
	Non-resorbable bone allografts and method for making same
Richard John Miron, Venice, FL (US)
Assigned to Miron Research and Development in Dentistry, LLC, Venice, FL (US)
Filed by Miron Research and Development in Dentistry, LLC, Venice, FL (US)
Filed on Oct. 22, 2019, as Appl. No. 16/659,604.
Claims priority of provisional application 62/751,298, filed on Oct. 26, 2018.
Prior Publication US 2020/0129668 A1, Apr. 30, 2020
Int. Cl. A61L 27/36 (2006.01); A61L 2/04 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61P 19/08 (2006.01)

CPC A61L 27/3691 (2013.01) [A61L 2/04 (2013.01); A61L 27/3608 (2013.01); A61L 27/3683 (2013.01); A61L 27/3687 (2013.01); A61L 27/3847 (2013.01); A61P 19/08 (2018.01); A61L 2430/12 (2013.01)]

9 Claims

1. A method for making a non-resorbable bone allograft, the method comprising:

excising a bone allograft from a human donor's body;

freeze-drying the bone allograft;

thermal processing a first set of the freeze-dried bone allograft, wherein the first set of the freeze-dried bone allograft is mineralized, and wherein the thermal processing is performed:

(i) at a temperature about 1,200 degrees Celsius for about one hour;

(ii) at a temperature about 900 degrees Celsius for about four hours; or

(iii) at a temperature about 300 degrees Celsius for about twelve hours, thus forming a non-resorbable, mineralized first set of bone allograft; and

preserving and sterilizing the non-resorbable, mineralized first set of bone allograft.