US 12,220,498 B2
In situ solidifying solutions and methods of making and using thereof
Russell J. Stewart, Salt Lake City, UT (US)
Assigned to UNIVERSITY OF UTAH RESEARCH FOUNDATION, Salt Lake City, UT (US)
Filed by UNIVERSITY OF UTAH RESEARCH FOUNDATION, Salt Lake City, UT (US)
Filed on Sep. 12, 2022, as Appl. No. 17/931,242.
Application 17/931,242 is a continuation of application No. 16/912,830, filed on Jun. 26, 2020, granted, now 11,471,557.
Application 16/912,830 is a continuation of application No. 16/450,338, filed on Jun. 24, 2019, granted, now 10,729,807, issued on Aug. 4, 2020.
Application 16/450,338 is a continuation of application No. 15/880,650, filed on Jan. 26, 2018, granted, now 10,369,249, issued on Aug. 6, 2019.
Application 15/880,650 is a continuation of application No. 15/325,885, granted, now 9,913,927, issued on Mar. 13, 2018, previously published as PCT/US2015/040377, filed on Jul. 14, 2015.
Claims priority of provisional application 62/024,128, filed on Jul. 14, 2014.
Prior Publication US 2023/0056283 A1, Feb. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 24/10 (2006.01); A61K 49/00 (2006.01); A61L 24/00 (2006.01); A61L 24/02 (2006.01); A61L 24/04 (2006.01); C09D 5/16 (2006.01)
CPC A61L 24/046 (2013.01) [A61K 49/0043 (2013.01); A61K 49/0054 (2013.01); A61K 49/0073 (2013.01); A61L 24/0015 (2013.01); A61L 24/0031 (2013.01); A61L 24/0042 (2013.01); A61L 24/02 (2013.01); A61L 24/043 (2013.01); A61L 24/10 (2013.01); A61L 24/104 (2013.01); C09D 5/1668 (2013.01); A61L 2300/416 (2013.01); A61L 2300/44 (2013.01); A61L 2430/02 (2013.01); A61L 2430/36 (2013.01)] 30 Claims
 
1. An injectable solution comprising water, at least one polycation, at least one polyanion, and a concentration of monovalent ions in water sufficient to prevent association of the polycation and polyanion, wherein the concentration of the monovalent ions in the injectable solution is greater than the concentration of the monovalent ions at an application site, whereupon introduction of the injectable solution at the application site a solid or gel is produced in situ,
wherein the total positive/negative charge ratio of the polycation to the polyanion is from 4 to 0.25 and the concentration of each monovalent ion in the injectable solution is from 0.5 M to 2.0 M.