US 12,220,496 B2
Prefilled syringe and method of preparing a prefilled syringe
Markus Hemminger, Basel (CH); Ulla Grauschopf, Basel (CH); Frank Bamberg, Basel (CH); Mayumi Bowen, South San Francisco, CA (US); Robert Müller, Basel (CH); Flora Felsovalyi, Basel (CH); and Denny Christensen, South San Francisco, CA (US)
Assigned to F. HOFFMANN-LA ROCHE AG, Basel (CH); and GENENTECH, INC., South San Francisco, CA (US)
Filed by F. HOFFMANN-LA ROCHE AG, Basel (CH); and GENENTECH, INC., South San Francisco, CA (US)
Filed on Jun. 6, 2023, as Appl. No. 18/330,083.
Application 18/330,083 is a division of application No. 16/651,444, granted, now 11,738,106, previously published as PCT/EP2018/076446, filed on Sep. 28, 2018.
Claims priority of provisional application 62/565,348, filed on Sep. 29, 2017.
Prior Publication US 2023/0310681 A1, Oct. 5, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 11/00 (2006.01); A61L 2/00 (2006.01); A61L 2/20 (2006.01); A61L 9/00 (2006.01); A61M 5/00 (2006.01); A61M 5/31 (2006.01); A61M 5/315 (2006.01); A61M 5/32 (2006.01); B65B 3/00 (2006.01); B65B 7/28 (2006.01); B65B 55/10 (2006.01); B65B 55/02 (2006.01)
CPC A61L 2/206 (2013.01) [A61M 5/001 (2013.01); A61M 5/002 (2013.01); A61M 5/3129 (2013.01); A61M 5/315 (2013.01); A61M 5/3202 (2013.01); B65B 3/003 (2013.01); B65B 7/2821 (2013.01); B65B 55/10 (2013.01); A61L 2202/23 (2013.01); A61L 2202/24 (2013.01); A61M 2005/3104 (2013.01); A61M 2005/3114 (2013.01); A61M 5/31513 (2013.01); A61M 2205/0238 (2013.01); A61M 2207/00 (2013.01); A61M 2207/10 (2013.01); B65B 55/02 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A prefilled syringe comprising:
a syringe barrel having an open end and a tip with an orifice essentially opposite to the open end;
a needle adaptor cap assembled on the tip of the syringe barrel, wherein the needle adaptor cap has a rubber element tightly sealing the orifice of the tip of the syringe barrel;
a drug substance arranged in an interior of the syringe barrel; and
a rubber stopper sealing the interior of the syringe barrel,
wherein the rubber element of the needle adaptor cap and the rubber stopper are made of a rubber material having an oxygen transmission rate at 1 atmosphere of not more than 120 cubic centimeter per square meter and day, of between 115 cubic centimeter per square meter and day and 116 cubic centimeter per square meter and day, of not more than 110 cubic centimeter per square meter and day, of not more than 100 cubic centimeter per square meter and day, of not more than 90 cubic centimeter per square meter and day, of not more than 80 cubic centimeter per square meter and day, of not more than 70 cubic centimeter per square meter and day, of not more than 65 cubic centimeter per square meter and day, of between 63 cubic centimeter per square meter and day and 64 cubic centimeter per square meter and day, or of about 63.6 cubic centimeter per square meter and day.