US 12,220,481 B2
Buccal micro-effervescent tablet and preparation method thereof
Jingqiang Wei, Guangdong (CN); Yuanying Huang, Guangdong (CN); Xuguang Zhang, Guangdong (CN); Meijuan Liu, Guangdong (CN); and Wenqiong Mai, Guangdong (CN)
Assigned to BYHEALTH CO., LTD., Guangdong (CN)
Appl. No. 17/286,322
Filed by BYHEALTH CO., LTD., Guangdong (CN)
PCT Filed Jun. 26, 2019, PCT No. PCT/CN2019/092936
§ 371(c)(1), (2) Date Apr. 16, 2021,
PCT Pub. No. WO2020/078036, PCT Pub. Date Apr. 23, 2020.
Claims priority of application No. 201811208708.0 (CN), filed on Oct. 17, 2018.
Prior Publication US 2022/0000770 A1, Jan. 6, 2022
Int. Cl. A61K 9/00 (2006.01); A23L 5/30 (2016.01); A23L 27/00 (2016.01); A23L 27/30 (2016.01); A23L 29/00 (2016.01); A23L 29/30 (2016.01); A23L 33/15 (2016.01); A23L 33/155 (2016.01); A23P 10/28 (2016.01); A61K 9/20 (2006.01); A61K 9/46 (2006.01); A61K 31/375 (2006.01)
CPC A61K 9/0056 (2013.01) [A23L 5/30 (2016.08); A23L 27/36 (2016.08); A23L 33/155 (2016.08); A61K 9/2009 (2013.01); A61K 9/2018 (2013.01); A61K 9/2095 (2013.01)] 5 Claims
 
1. A buccal micro-effervescent tablet comprising:
a nutrient, wherein the nutrient is Vitamin C;
a sugar alcohol, wherein the sugar alcohol is a combination of lactose and maltitol and wherein the ratio of lactose to maltitol is 1:2.2-1:4.5 in parts by weight;
an acid source, wherein the acid source is citric acid, tartaric acid, fumaric acid, malic acid, or any combination thereof;
an alkali source, wherein the alkali source is sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate or any combination thereof;
a magnesium stearate;
an essence; and
a sweetening agent, wherein the sweetening agent is a combination of sucralose, aspartame and stevioside,
wherein the buccal micro-effervescent tablet comprises in parts by weight: 8-12 parts of the nutrient, 10-80 parts of the sugar alcohol, 11-19 parts of the acid source, 11-18 parts of the alkali source, 0.1-3 parts of the magnesium stearate, 1-5 parts of the essence and 0.1-3 parts of the sweetening agent.