US 12,220,467 B2
Highly loaded metal oxide materials by self-assembly for extended biologically active molecule release in medical and dental applications
Cameron Alexander Stewart, Springwater (CA); Benjamin David Hatton, Toronto (CA); and Yoav Finer, Toronto (CA)
Assigned to MESOSIL INC., Toronto (CA)
Filed by MESOSIL INC., Toronto (CA)
Filed on Aug. 31, 2021, as Appl. No. 17/463,002.
Application 17/463,002 is a continuation of application No. 16/301,773, granted, now 11,129,774, previously published as PCT/CA2017/050586, filed on May 16, 2017.
Claims priority of provisional application 62/337,016, filed on May 16, 2016.
Prior Publication US 2022/0000722 A1, Jan. 6, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 6/84 (2020.01); A01N 25/08 (2006.01); A01N 43/40 (2006.01); A01N 47/44 (2006.01); A61K 6/20 (2020.01); A61K 6/35 (2020.01); A61K 6/40 (2020.01); A61K 6/54 (2020.01); A61K 6/71 (2020.01); A61K 6/74 (2020.01); A61K 6/76 (2020.01); A61K 6/80 (2020.01); A61K 6/802 (2020.01); A61K 6/849 (2020.01); A61K 6/853 (2020.01); A61K 6/86 (2020.01); A61K 6/864 (2020.01); A61K 6/871 (2020.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 9/51 (2006.01); A61K 31/155 (2006.01); A61K 31/20 (2006.01); A61K 31/4425 (2006.01); A61K 31/444 (2006.01); A61K 31/785 (2006.01); A61L 27/02 (2006.01); A61L 27/10 (2006.01); A61L 27/12 (2006.01); A61L 27/30 (2006.01); A61L 27/32 (2006.01); A61L 27/42 (2006.01); A61L 27/44 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); A61P 1/02 (2006.01); A61P 31/02 (2006.01); A61P 31/04 (2006.01); C07C 279/14 (2006.01); C07C 279/26 (2006.01); C07D 213/20 (2006.01); C07D 213/74 (2006.01); C08K 3/22 (2006.01); C08K 3/32 (2006.01); C08L 33/10 (2006.01); C08L 33/12 (2006.01); C08L 75/04 (2006.01)
CPC A61K 6/84 (2020.01) [A01N 25/08 (2013.01); A01N 43/40 (2013.01); A01N 47/44 (2013.01); A61K 6/20 (2020.01); A61K 6/35 (2020.01); A61K 6/40 (2020.01); A61K 6/54 (2020.01); A61K 6/71 (2020.01); A61K 6/74 (2020.01); A61K 6/76 (2020.01); A61K 6/80 (2020.01); A61K 6/802 (2020.01); A61K 6/849 (2020.01); A61K 6/853 (2020.01); A61K 6/86 (2020.01); A61K 6/864 (2020.01); A61K 6/871 (2020.01); A61K 9/0024 (2013.01); A61K 9/0063 (2013.01); A61K 9/143 (2013.01); A61K 9/5115 (2013.01); A61K 31/155 (2013.01); A61K 31/20 (2013.01); A61K 31/4425 (2013.01); A61K 31/444 (2013.01); A61K 31/785 (2013.01); A61L 27/025 (2013.01); A61L 27/10 (2013.01); A61L 27/105 (2013.01); A61L 27/12 (2013.01); A61L 27/306 (2013.01); A61L 27/32 (2013.01); A61L 27/425 (2013.01); A61L 27/427 (2013.01); A61L 27/446 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61P 1/02 (2018.01); A61P 31/02 (2018.01); A61P 31/04 (2018.01); C07C 279/14 (2013.01); C07C 279/26 (2013.01); C07D 213/20 (2013.01); C07D 213/74 (2013.01); C08K 3/22 (2013.01); C08K 3/32 (2013.01); C08L 33/12 (2013.01); A61L 2300/206 (2013.01); A61L 2300/208 (2013.01); A61L 2300/404 (2013.01); C08K 2003/2227 (2013.01); C08K 2003/2237 (2013.01); C08K 2003/2296 (2013.01); C08K 2003/325 (2013.01); C08L 2203/02 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A method of making a composite material comprising the steps of,
forming particles by providing a mixture of an amphiphilic biologically active agent, a metal oxide precursor and a solvent, wherein the amphiphilic biologically active agent is present in an amount sufficient to self-assemble into a micellar system, and wherein the metal oxide condenses around the micellar system, and
dispersing the particles comprising the biologically active agent in a resin,
wherein the biologically active agent comprises octenidine or a salt thereof.