US 12,220,461 B2
Polypeptide-coupled small molecule compound and antiviral application thereof
Xiyong Yu, Guangzhou (CN); Ao Shen, Guangzhou (CN); Hua Tao, Guangzhou (CN); Lixin Zhao, Guangzhou (CN); Nanshan Zhong, Guangzhou (CN); and Qiulian Zhu, Guangzhou (CN)
Assigned to Guangzhou Medical University, Guangzhou (CN)
Filed by Guangzhou Medical University, Guangzhou (CN)
Filed on May 17, 2024, as Appl. No. 18/667,958.
Claims priority of application No. 202310567902.2 (CN), filed on May 19, 2023.
Prior Publication US 2024/0382604 A1, Nov. 21, 2024
Int. Cl. A61K 47/64 (2017.01); A61P 31/14 (2006.01)
CPC A61K 47/64 (2017.08) [A61P 31/14 (2018.01)] 9 Claims
 
1. A peptide-coupled molecule compound, wherein the peptide comprises the amino acid sequence SRLRGG (SEQ ID NO: 1);
the molecule compound inhibits a coronavirus papain-like protease (PLpro) activity; and
wherein the C-terminal carboxyl group of the peptide and the molecule compound are chemically bound by an amide bond or an ester bond.