	US 12,220,458 B2
	Antigen-surface-coupled liposome vaccine for non-human animals
Tetsuya Uchida, Saitama (JP); Makoto Nakanishi, Sakura (JP); Ryouichi Shima, Sakura (JP); Takanori Namimatsu, Sakura (JP); and Goro Suzuki, Sakura (JP)
Assigned to NATIONAL FEDERATION OF AGRICULTURAL COOPERATIVE ASSOCIATIONS, Tokyo (JP); and Tetsuya Uchida, Saitama (JP)
Appl. No. 16/964,809
Filed by NATIONAL FEDERATION OF AGRICULTURAL COOPERATIVE ASSOCIATIONS, Tokyo (JP); and Tetsuya Uchida, Saitama (JP)
PCT Filed Jan. 24, 2019, PCT No. PCT/JP2019/002339 § 371(c)(1), (2) Date Jan. 22, 2021, PCT Pub. No. WO2019/146716, PCT Pub. Date Aug. 1, 2019.
Claims priority of application No. 2018-011939 (JP), filed on Jan. 26, 2018.
Prior Publication US 2021/0138064 A1, May 13, 2021
Int. Cl. A61K 39/385 (2006.01); A61K 39/12 (2006.01); A61K 39/215 (2006.01); A61K 47/69 (2017.01); A61P 31/14 (2006.01); A61K 39/00 (2006.01)

CPC A61K 39/385 (2013.01) [A61K 39/12 (2013.01); A61K 39/215 (2013.01); A61K 47/6911 (2017.08); A61P 31/14 (2018.01); A61K 2039/545 (2013.01); A61K 2039/552 (2013.01); A61K 2039/572 (2013.01); A61K 2039/575 (2013.01); A61K 2039/6018 (2013.01); C12N 2770/10034 (2013.01); C12N 2770/10071 (2013.01); C12N 2770/20034 (2013.01); C12N 2770/20071 (2013.01)]

10 Claims

1. A method for vaccinating poultry comprising:

administering a vaccine to poultry by fine spray administration with a droplet size of not more than 150 μm, said vaccine comprising liposomes each comprising an antigen molecule(s) bound to the surface thereof, the antigen molecule(s) being a full-length nucleocapsid protein of infectious bronchitis virus whose amino acid sequence is shown in SEQ ID NO:2.