	US 12,220,449 B2
	Enhancing T cell activation using altered MHC-peptide ligands
Larry R. Pease, Rochester, MN (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on Sep. 1, 2020, as Appl. No. 17/009,613.
Application 17/009,613 is a division of application No. 15/135,832, filed on Apr. 22, 2016, granted, now 10,792,348.
Application 15/135,832 is a continuation of application No. 13/299,754, filed on Nov. 18, 2011, abandoned.
Claims priority of provisional application 61/415,227, filed on Nov. 18, 2010.
Prior Publication US 2020/0397877 A1, Dec. 24, 2020
Int. Cl. C12N 7/00 (2006.01); A61K 35/17 (2015.01); A61K 39/00 (2006.01); C07K 14/74 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); A61K 38/00 (2006.01)

CPC A61K 39/0011 (2013.01) [A61K 35/17 (2013.01); A61K 39/0008 (2013.01); A61K 39/001106 (2018.08); A61K 39/00115 (2018.08); A61K 39/001151 (2018.08); A61K 39/001153 (2018.08); A61K 39/001156 (2018.08); A61K 39/001157 (2018.08); A61K 39/001162 (2018.08); A61K 39/00117 (2018.08); A61K 39/001182 (2018.08); A61K 39/001186 (2018.08); A61K 39/001188 (2018.08); A61K 39/001191 (2018.08); A61K 39/001192 (2018.08); A61K 39/001193 (2018.08); A61K 39/001194 (2018.08); A61K 39/001197 (2018.08); A61K 39/4611 (2023.05); A61K 39/4621 (2023.05); A61K 39/46433 (2023.05); C07K 14/70539 (2013.01); C12N 7/00 (2013.01); G01N 33/505 (2013.01); G01N 33/56977 (2013.01); A61K 38/00 (2013.01); A61K 2039/53 (2013.01); A61K 2039/572 (2013.01); C12N 2710/10043 (2013.01); G01N 2333/70539 (2013.01)]

2 Claims

1. A virus particle comprising a nucleic acid that encodes a variant of a wild-type human HLA-A0201 molecule consisting of a non-conservative amino acid substitution of G¹⁶²to tryptophan, tyrosine, or phenylalanine.