	US 12,220,446 B2
	Use of upstream open reading frame 45aa-uORF nucleotide sequence of PTEN gene and polypeptide coded by 45aa-uORF
Nu Zhang, Guangdong (CN)
Assigned to THE FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY, Guangdong (CN)
Appl. No. 16/620,154
Filed by THE FIRST AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY, Guangdong (CN)
PCT Filed Jun. 8, 2018, PCT No. PCT/CN2018/090520 § 371(c)(1), (2) Date Dec. 6, 2019, PCT Pub. No. WO2018/224044, PCT Pub. Date Dec. 13, 2018.
Claims priority of application No. 201710429319.X (CN), filed on Jun. 8, 2017.
Prior Publication US 2020/0138915 A1, May 7, 2020
Int. Cl. C12N 15/55 (2006.01); A61K 31/713 (2006.01); A61K 38/17 (2006.01); A61K 38/46 (2006.01); A61K 48/00 (2006.01); C07K 14/435 (2006.01); C12N 9/16 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01)

CPC A61K 38/465 (2013.01) [A61K 31/713 (2013.01); A61K 38/1703 (2013.01); A61K 48/00 (2013.01); C07K 14/435 (2013.01); C12Q 1/6886 (2013.01); C12Y 301/03067 (2013.01); G01N 33/57496 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/916 (2013.01)]

3 Claims

1. A method for treating a glioma tumor in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a polypeptide, wherein the polypeptide consists of the amino acid sequence of SEQ ID NO: 2.