US 12,220,420 B2
Combination therapy for cancer treatment
Robert A. Beardsley, University City, MO (US); Dennis P. Riley, Chesterfield, MO (US); Jeffery L. Keene, St. Louis, MO (US); Douglas R. Spitz, Iowa City, IA (US); and Melissa A. Fath, Iowa City, IA (US)
Assigned to Galera Labs, LLC, Malvern, PA (US)
Appl. No. 16/098,026
Filed by Galera Labs, LLC, Creve Coeur, MO (US)
PCT Filed May 3, 2017, PCT No. PCT/US2017/030871
§ 371(c)(1), (2) Date Oct. 31, 2018,
PCT Pub. No. WO2017/192740, PCT Pub. Date Nov. 9, 2017.
Claims priority of provisional application 62/331,253, filed on May 3, 2016.
Prior Publication US 2019/0151331 A1, May 23, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/555 (2006.01); A61K 31/198 (2006.01); A61K 31/4196 (2006.01); A61K 31/635 (2006.01); A61K 31/655 (2006.01); A61K 31/70 (2006.01); A61K 31/7135 (2006.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01); A61P 35/00 (2006.01)
CPC A61K 31/555 (2013.01) [A61K 31/198 (2013.01); A61K 31/4196 (2013.01); A61K 31/635 (2013.01); A61K 31/655 (2013.01); A61K 31/70 (2013.01); A61K 31/7135 (2013.01); A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); A61P 35/00 (2018.01)] 21 Claims
 
1. A method of treating a cancer in a mammalian subject afflicted therewith, the cancer being selected from the group consisting of breast cancer, and lung cancer, the method comprising:
administering to the subject at least one active agent comprising a thioredoxin reductase inhibitor;
wherein the thioredoxin reductase inhibitor is auranofin; and
administering to the subject a pentaaza macrocyclic ring complex corresponding to formulae (II), (III) or (IV) below:

OG Complex Work Unit Chemistry
wherein
X and Y are independently selected from any one or more of: (i) the group consisting of fluoro, chloro, bromo, and iodo anions; (ii) the group consisting of alkyl carboxylates, aryl carboxylates and arylalkyl carboxylates; and (iii) amino acids; and
RA, RB, RC, and RD are independently hydrogen or hydrocarbyl.