US 12,220,404 B2
Treatment and management of augmentation in restless legs syndrome
Stefan Clemens, Greenville, NC (US); and Perrine Lallemand, Frederick, MD (US)
Assigned to East Carolina University, Greenville, NC (US)
Filed by East Carolina University, Greenville, NC (US)
Filed on Jul. 17, 2020, as Appl. No. 16/932,352.
Application 16/932,352 is a continuation of application No. 15/753,149, granted, now 10,751,327, previously published as PCT/US2016/047591, filed on Aug. 18, 2016.
Claims priority of provisional application 62/207,225, filed on Aug. 19, 2015.
Prior Publication US 2021/0169859 A1, Jun. 10, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A01N 37/00 (2006.01); A01N 25/00 (2006.01); A01N 37/12 (2006.01); A01N 37/44 (2006.01); A61K 31/215 (2006.01); A61K 31/24 (2006.01); A61K 31/381 (2006.01); A61K 31/40 (2006.01); A61K 31/428 (2006.01); A61K 31/48 (2006.01); A61K 31/485 (2006.01); A61K 31/5383 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01); A61P 43/00 (2006.01); A61K 9/00 (2006.01)
CPC A61K 31/428 (2013.01) [A61K 31/381 (2013.01); A61K 31/40 (2013.01); A61K 31/48 (2013.01); A61K 31/485 (2013.01); A61K 31/5383 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); A61P 43/00 (2018.01); A61K 9/0019 (2013.01); A61K 2300/00 (2013.01)] 12 Claims
 
1. A method of treating augmentation associated with restless legs syndrome (RLS) treatment in a subject in need thereof, comprising administering to the subject an effective amount of ecopipam, thereby treating augmentation in the subject.