US 12,220,354 B2
Enhancing optical detection of micro bubbles by laser pulse expansion
Mordehai Margalit, Zikhron Ya'akov (IL)
Assigned to Lutronic Vision Inc.
Filed by Lutronic Vision Inc, Berlington, MA (US)
Filed on Dec. 8, 2022, as Appl. No. 18/063,533.
Application 18/063,533 is a continuation of application No. 16/758,241, granted, now 11,547,606, previously published as PCT/US2017/057768, filed on Oct. 22, 2017.
Prior Publication US 2023/0104449 A1, Apr. 6, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 9/008 (2006.01)
CPC A61F 9/0084 (2013.01) [A61F 2009/00844 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of therapeutic radiation dosimetry to a treatment location of a patient, the method comprising:
irradiating radiation pulses on the treatment location, wherein each radiation pulse includes a therapeutic portion and a probe portion, the therapeutic portion being immediately followed by the probe portion to form a single aggregate pulse, the therapeutic portion having at least a first intensity and the probe portion having a second intensity less than the first intensity, wherein each therapeutic portion of each radiation pulse is configured to cause a status of tissue to change in the treatment location,
collecting reflected radiation pulses from the treatment location of the patient, wherein each reflected radiation pulse includes a reflected therapeutic portion and a reflected probe portion; and
generating a photocurrent from the collected reflected radiation pulses, the photocurrent being indicative of changing the status of the tissue in the treatment location.
 
10. A laser-based surgical system, comprising:
a therapeutic radiation source configured to emit radiation pulses into a treatment location, wherein each radiation pulse includes a therapeutic portion and a probe portion, the therapeutic portion being immediately followed by the probe portion to form a single aggregate pulse, the therapeutic portion having at least a first intensity and the probe portion having a second intensity less than the first intensity, wherein the therapeutic portion is configured to cause a status of tissue to change in the treatment location;
one or more optical elements configured to direct the radiation pulses into the treatment location of the patient and to collect reflected radiation pulses from the treatment location of the patient, wherein each reflected radiation pulse includes a reflected therapeutic portion and a reflected probe portion; and
a photodetector configured to receive the reflected radiation pulses from the one or more optical elements and to generate from the reflected radiation pulses a photocurrent indicative of dynamics of changing the status of tissue in the treatment location.
 
20. A method of therapeutic radiation dosimetry to a treatment location of a patient, the method comprising:
irradiating the treatment location of the patient with radiation pulses, wherein each radiation pulse includes a therapeutic portion with at least a first intensity followed by a probe portion with a second intensity less than the first intensity, wherein each therapeutic portion of each radiation pulse is configured to cause a status of tissue in the treatment location to change;
detecting a damage of the tissue by collecting reflected radiation pulses from the treatment location of the patient to perform a real-time feedback during the irradiating and stop the irradiating based on the feedback, wherein each reflected radiation pulse includes a reflected therapeutic portion and a reflected probe portion; and
generating a photocurrent from the collected reflected radiation pulses, the photocurrent being indicative of dynamics of the damage of the tissue of the treatment location.