US 12,220,273 B2
Perfusion angiography combined with photoplethysmography imaging for peripheral vascular disease assessment
Bernardus Hendrikus Wilhelmus Hendriks, Eindhoven (NL); Maria-Louisa Izamis, Cambridge, MA (US); and Caifeng Shan, Veldhoven (NL)
Assigned to KONINKLIJJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 17/767,756
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Oct. 13, 2020, PCT No. PCT/EP2020/078680
§ 371(c)(1), (2) Date Apr. 8, 2022,
PCT Pub. No. WO2021/074097, PCT Pub. Date Apr. 22, 2021.
Claims priority of application No. 19202888 (EP), filed on Oct. 14, 2019.
Prior Publication US 2024/0081766 A1, Mar. 14, 2024
Int. Cl. A61B 6/00 (2024.01); A61B 6/46 (2024.01); A61B 6/50 (2024.01); G16H 30/40 (2018.01)
CPC A61B 6/5217 (2013.01) [A61B 6/4417 (2013.01); A61B 6/463 (2013.01); A61B 6/481 (2013.01); A61B 6/507 (2013.01); A61B 6/5247 (2013.01); A61B 6/5264 (2013.01); G16H 30/40 (2018.01)] 17 Claims
OG exemplary drawing
 
11. A method for processing perfusion images, the method comprising:
providing a first image sequence comprising a plurality of X-ray angiography images indicative of first perfusion states relative to deep tissue of an organ being perfused during imaging, and
providing a second image sequence comprising a plurality of two-dimensional photoplethysmography images indicative of second perfusion states relative to surface tissue or near surface tissue of the organ being perfused during the imaging, each of the plurality of two-dimensional photoplethysmography images comprising a plurality of image points associated with blood volume values at a corresponding plurality of distinct spatial locations on a surface of the organ,
extracting first changes in the first perfusion states over time from the first image sequence and second changes in the second perfusion states over time from the second image sequence,
aligning the first changes and the second changes, or a quantity derived therefrom, in time by detecting a reduction of image signal amplitude in the second image sequence of the plurality of two-dimensional photoplethysmography images caused by a passage of a previously delivered contrast agent bolus, and
generating an image for display, the image comprising a plurality of image signals indicating the aligned first changes and second changes, or the quantity derived therefrom, at a plurality of perfused organ tissue locations.