US 12,220,212 B2
Phenotyping sensor patterns to identify and treat heart failure
Melanie Anne Zile, Baltimore, MD (US); Pramodsingh Hirasingh Thakur, Woodbury, MN (US); and Qi An, Blaine, MN (US)
Assigned to Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed by Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed on Dec. 4, 2017, as Appl. No. 15/830,893.
Claims priority of provisional application 62/431,050, filed on Dec. 7, 2016.
Prior Publication US 2018/0153416 A1, Jun. 7, 2018
Int. Cl. A61B 5/0205 (2006.01); A61B 5/00 (2006.01); A61N 1/362 (2006.01); A61N 1/365 (2006.01); A61N 1/372 (2006.01); A61N 1/39 (2006.01); A61B 5/024 (2006.01); A61B 5/0531 (2021.01); A61B 5/08 (2006.01); A61B 5/11 (2006.01); A61B 7/04 (2006.01)
CPC A61B 5/02055 (2013.01) [A61B 5/7246 (2013.01); A61B 5/7264 (2013.01); A61N 1/3627 (2013.01); A61N 1/36585 (2013.01); A61N 1/37252 (2013.01); A61N 1/3956 (2013.01); A61N 1/39622 (2017.08); A61B 5/024 (2013.01); A61B 5/0531 (2013.01); A61B 5/0816 (2013.01); A61B 5/1118 (2013.01); A61B 7/04 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for managing heart failure alerts through a communication link comprising:
a sensing circuit including a heart sound sensor configured to sense a heart sound signal of a patient, a heart rate sensor configured to sense a heart rate signal of the patient, and a respiration sensor configured to sense a respiratory signal of the patient;
a signal analysis circuit configured to receive physiologic information from the sensing circuit and to generate a heart failure status for the patient using the received physiologic information; and
a control circuit configured to classify the generated heart failure status into at least one of a set of predetermined phenotype clusters using the received physiologic information,
wherein the received physiologic information comprises respective first, second, third, fourth, and fifth physiologic measures of the patient, wherein the first physiologic measure comprises third heart sound (S3) information from the heart sound sensor, wherein the second physiologic measure comprises the S3 information normalized by first heart sound (S1) information from the heart sound sensor, wherein the third physiologic measure comprises rapid shallow breathing index (RSBI) information from the respiration sensor, wherein the fourth physiologic measure comprises respiratory rate information from the respiration sensor, and wherein the fifth physiologic measure comprises heart rate information from the heart rate sensor,
wherein to generate the heart failure status for the patient, the signal analysis circuit is configured to determine a numerical index value for each of the first, second, third, fourth, and fifth physiological measures based on a statistical analysis of stored values of each respective physiological measure, to determine a composite index using the determined numerical index values, and to generate the heart failure status based on a value of the composite index,
wherein to classify the generated heart failure status into the at least one of the set of predetermined phenotype clusters, the control circuit is configured to determine changes in the first, second, third, fourth, and fifth physiologic measures and to compare the determined changes to respective thresholds, the respective thresholds including, for each respective physiologic measure, a threshold percentage of an upper value of a predetermined patient-specific or population range or a threshold amount above a patient-specific or population average for the respective physiologic measure, and:
to classify the generated heart failure status into a first cluster if the determined changes in the third, fourth, and fifth physiologic measures are above their respective thresholds and the determined changes in the first and second physiologic measures are below their respective thresholds;
to classify the generated heart failure status into a second cluster if the determined change in the second physiologic measure is above its respective threshold and the determined changes in the first, third, fourth, and fifth physiologic measures are below their respective thresholds; and
to classify the generated heart failure status into a third cluster if the determined changes in the second and third physiologic measures are above their respective thresholds and the determined changes in the first, fourth, and fifth physiologic measures are below their respective thresholds,
wherein the control circuit is configured to automatically provide an alert for the generated heart failure status through the communication link if the generated heart failure status is classified into one of the second or third clusters and to automatically withhold the alert for the generated heart failure status, omitting the alert through the communication link, if the generated heart failure status is classified into the first cluster.