US 12,220,203 B2
Systems and methods for real-time target validation for image-guided radiation therapy
John Rodenbeck Adler, Jr., Stanford, CA (US); Jianing Shi, Houston, TX (US); and James E. Clayton, San Jose, CA (US)
Assigned to VARIAN MEDICAL SYSTEMS, INC., Palo Alto, CA (US)
Filed by Varian Medical Systems, Inc., Palo Alto, CA (US)
Filed on Oct. 18, 2023, as Appl. No. 18/381,403.
Application 18/381,403 is a continuation of application No. 18/108,713, filed on Feb. 13, 2023, granted, now 11,819,308.
Application 18/108,713 is a continuation of application No. 17/707,290, filed on Mar. 29, 2022, granted, now 11,607,130, issued on Mar. 21, 2023.
Application 17/707,290 is a continuation of application No. 16/843,970, filed on Apr. 9, 2020, granted, now 11,330,982, issued on May 17, 2022.
Application 16/843,970 is a continuation of application No. 15/066,050, filed on Mar. 10, 2016, granted, now 10,674,915, issued on Jun. 9, 2020.
Application 15/066,050 is a continuation of application No. 13/691,502, filed on Nov. 30, 2012, granted, now 9,314,160, issued on Apr. 19, 2016.
Claims priority of provisional application 61/565,900, filed on Dec. 1, 2011.
Prior Publication US 2024/0041326 A1, Feb. 8, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G06K 9/00 (2022.01); A61B 5/00 (2006.01); A61B 6/12 (2006.01); A61B 6/46 (2024.01); A61N 5/10 (2006.01); A61B 6/02 (2006.01)
CPC A61B 5/0036 (2018.08) [A61B 6/12 (2013.01); A61B 6/463 (2013.01); A61B 6/466 (2013.01); A61N 5/1049 (2013.01); A61N 5/1064 (2013.01); A61N 5/1067 (2013.01); A61N 5/107 (2013.01); A61B 6/025 (2013.01); A61N 2005/1062 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for generating a repositioning signal for adjusting a target volume relative to an isocenter of a radiation therapy device, comprising:
a computer processing device configured to:
obtain images from the radiation therapy device, the images having been generated by irradiating the target volume with radiation beams at a series of projection angles;
determine trajectories of radiation beams through the target volume from the generated images;
determine a measure of correlation between the determined beam trajectories and corresponding reference beam trajectories, the reference beam trajectories having been obtained from reference images of the target volume at the series of projection angles;
evaluate the measure of correlation over the series of projection angles;
determine a change in the measure of correlation;
determine a displacement of the target volume based on the determined change in the measure of correlation; and
generate a repositioning signal based on the determined displacement,
wherein the repositioning signal indicates an amount and direction of adjustment for the target volume relative to the isocenter.