| CPC A61B 17/3403 (2013.01) [A61B 17/3478 (2013.01); A61B 2017/00115 (2013.01); A61B 2560/0487 (2013.01)] | 20 Claims |

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1. A system comprising:
control circuitry; and
memory communicatively couped to the control circuitry and storing executable instructions that, when executed by the control circuitry, cause the control circuitry to perform operations comprising:
receiving first sensor data from a first medical instrument that is configured to access anatomy via an incision;
determining an orientation of the first medical instrument based on the first sensor data;
receiving second sensor data from a second medical instrument that is configured to access the anatomy through an anatomical lumen;
determining a target trajectory to access the anatomy based on the second sensor data; and
generating alignment data indicative of an alignment of the orientation of the first medical instrument to the target trajectory.
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