	US RE50,288 E1
	Factor IX polypeptide mutant, its uses and a method for its production
Paolo Simioni, Padua (IT)
Assigned to UNIQURE BIOPHARMA B.V., Amsterdam (NL)
Appl. No. 18/153,894
Filed by UNIQURE BIOPHARMA B.V., Amsterdam (NL)
PCT Filed Sep. 15, 2009, PCT No. PCT/EP2009/061935 § 371(c)(1), (2), (4) Date May 31, 2011, PCT Pub. No. WO2010/029178, PCT Pub. Date Mar. 18, 2010.
Application 18/153,894 is a reissue of application No. 13/063,898, filed on Sep. 15, 2009, granted, now 9,249,405, issued on Feb. 2, 2016.
Claims priority of application No. BO2008A000564 (IT), filed on Sep. 15, 2008; and application No. BO2009A000275 (IT), filed on May 6, 2009.
Int. Cl. A61P 7/04 (2006.01); A61K 38/48 (2006.01); C12N 9/64 (2006.01)

CPC C12N 9/644 (2013.01) [A61K 38/4846 (2013.01); A61P 7/04 (2018.01); C12Y 304/21022 (2013.01)]

7 Claims

8. [ A nucleotide sequence encoding a modified FIX (Factor IV) polypeptide comprising 100% identity to SEQ ID NO: 2 except for an alanine at position 148 and a leucine at position 338 of SEQ ID NO: 2 in combination with positions corresponding to positions 34098, 34099 and 34100 of a sequence having accession number K02402 (GenBank) having a triplet selected from the ] group consisting of: ~~TTA, UUA, TTG, UUG, CTT, CUU,~~ CTC, CUC, ~~CTA, CUA,~~ CTG, [ and ] CUG ~~, GAT, GAU and GAC~~.