US 12,217,952 B2
Mass correction
Martin Raymond Green, Bowdon (GB)
Assigned to Micromass UK Limited, Wilmslow (GB)
Filed by Micromass UK Limited, Wilmslow (GB)
Filed on May 12, 2021, as Appl. No. 17/318,202.
Application 17/318,202 is a continuation of application No. 14/990,928, filed on Jan. 8, 2016, granted, now 11,031,217.
Claims priority of application No. 1500377 (GB), filed on Jan. 9, 2015.
Prior Publication US 2021/0265148 A1, Aug. 26, 2021
Int. Cl. H01J 49/00 (2006.01); G01N 30/86 (2006.01)
CPC H01J 49/0036 (2013.01) [G01N 30/86 (2013.01); G01N 30/8679 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of mass spectrometry comprising the steps of:
providing a library of matrix data, said matrix data comprising one or more physico-chemical properties of one or more matrix components;
ion imaging a sample at a plurality of spatial locations, said sample containing at least some of said matrix components and one or more analyte components;
mass analyzing ions from said sample at said plurality of spatial locations to obtain sample data comprising one or more physico-chemical properties of one or more sample components;
calculating one or more error values based on a comparison between said sample data and said matrix data, wherein each error value is associated with a given spatial location; and
adjusting or correcting one or more instrument parameters using adjustment or correction values, and wherein said one or more instrument parameters comprises one or more of detector gain, transmission efficiency, ionization efficiency, time of flight voltage and reflection voltage.