US 12,217,843 B2
Bolus calculator with probabilistic carbohydrate measurements
David L. Duke, Fishers, IN (US)
Assigned to Roche Diabetes Care, Inc., Indianapolis, IN (US)
Filed by Roche Diabetes Care, Inc., Indianapolis, IN (US)
Filed on Apr. 17, 2019, as Appl. No. 16/386,696.
Application 16/386,696 is a continuation of application No. 15/140,550, filed on Apr. 28, 2016, granted, now 10,311,976.
Prior Publication US 2019/0244715 A1, Aug. 8, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. G16H 20/10 (2018.01); G16H 20/60 (2018.01); G16H 50/30 (2018.01)
CPC G16H 20/10 (2018.01) [G16H 20/60 (2018.01); G16H 50/30 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A method of using a bolus calculator to account for an uncertainty of a carbohydrate estimate to reduce a risk of hypoglycemia comprising:
providing the bolus calculator containing therewithin a processor that when activated executes an algorithm defining pre-set values for:
a first threshold percentage defining a probability of hypoglycemia (Phypo); and
a hypoglycemia threshold (Thypo);
calculating, by the bolus calculator, a measure defining the uncertainty of the carbohydrate estimate (c) as a standard deviation (σc) based on (i) at least an assessment of an ability of a user to count carbohydrates from a test, (ii) a history of the user, or (iii) combination thereof;
providing to the bolus calculator the carbohydrate estimate;
activating the processor to execute the algorithm to use the pre-set values, the carbohydrate estimate and the measure defining the uncertainty of the carbohydrate estimate to:
determine the probability of hypoglycemia if the carbohydrate estimate has overestimated the carbohydrate content and therefore a standard meal insulin bolus has been overestimated and thus should be adjusted to reduce the risk of hypoglycemia:
providing a recommendation to the user when the carbohydrate estimate has been overestimated to adjust a corresponding meal insulin bolus; and
administering the adjusted corresponding meal insulin bolus through a therapy delivery device operatively coupled to the bolus calculator to the user such that the administered adjusted corresponding meal insulin bolus affects a blood glucose value of the user to reduce the risk of hypoglycemia.