US 12,217,420 B2
Systems and methods for processing electronic images to determine testing for unstained specimens
Patricia Raciti, New York, NY (US); Christopher Kanan, Pittsford, NY (US); Alican Bozkurt, New York, NY (US); and Belma Dogdas, Ridgewood, NJ (US)
Assigned to Paige.AI, Inc., New York, NY (US)
Filed by PAIGE.AI, Inc., New York, NY (US)
Filed on Sep. 19, 2022, as Appl. No. 17/933,156.
Application 17/933,156 is a continuation of application No. 17/547,695, filed on Dec. 10, 2021, granted, now 11,481,899.
Application 17/547,695 is a continuation of application No. 17/457,451, filed on Dec. 3, 2021, granted, now 11,482,319.
Claims priority of provisional application 63/158,791, filed on Mar. 9, 2021.
Prior Publication US 2023/0020368 A1, Jan. 19, 2023
Int. Cl. G06T 7/00 (2017.01); G06N 3/045 (2023.01); G06T 11/00 (2006.01); G06V 10/77 (2022.01); G16H 30/20 (2018.01)
CPC G06T 7/0012 (2013.01) [G06N 3/045 (2023.01); G06T 11/001 (2013.01); G06V 10/7715 (2022.01); G16H 30/20 (2018.01); G06T 2207/30024 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A computer-implemented method, comprising:
receiving a collection of unstained digital histopathology slide images;
providing one or more unstained digital histopathology slide images of the collection to a trained machine learning model to infer a presence or an absence of a salient feature,
the trained machine learning model having been trained by processing a second collection of unstained and/or stained digital histopathology slide images and at least one synoptic annotation for one or more unstained and/or stained digital histopathology slide images of the second collection, wherein the processing comprises:
virtually staining one or more unstained digital histopathology slide images of the second collection to a stain or using an image processing technique to un-stain one or more stained digital histopathology slide images of the second collection; and
training a machine learning model to take as input one or more locations on a slide image to infer a presence of a salient label;
determining at least one map based on an output of the trained machine learning model, wherein the at least one map produces detection regions; and
utilizing the at least one map, to determine where the salient feature is located, in one or more tests related to the collection of unstained digital histopathology slide images.