US 12,216,185 B2
Systems and methods for generation of hyperpolarized compounds using parahydrogen
Ilai Schwartz, Neu-Ulm (DE); Michael Keim, Neu-Ulm (DE); and Stephan Knecht, Stuttgart (DE)
Assigned to NVISION IMAGING TECHNOLOGIES GMBH, Ulm (DE)
Appl. No. 18/256,202
Filed by NVISION IMAGING TECHNOLOGIES GMBH, Ulm (DE)
PCT Filed Dec. 7, 2021, PCT No. PCT/IB2021/000840
§ 371(c)(1), (2) Date Jun. 6, 2023,
PCT Pub. No. WO2022/157534, PCT Pub. Date Jul. 28, 2022.
Application 18/256,202 is a continuation in part of application No. PCT/IB2021/000493, filed on Jul. 23, 2021.
Claims priority of provisional application 63/201,151, filed on Apr. 15, 2021.
Claims priority of provisional application 63/122,006, filed on Dec. 7, 2020.
Claims priority of provisional application 63/076,411, filed on Sep. 10, 2020.
Claims priority of provisional application 63/055,367, filed on Jul. 23, 2020.
Prior Publication US 2024/0272252 A1, Aug. 15, 2024
Int. Cl. G01R 33/31 (2006.01); G01R 33/28 (2006.01); G01R 33/30 (2006.01); G01R 33/42 (2006.01); G01R 33/465 (2006.01)
CPC G01R 33/282 (2013.01) [G01R 33/307 (2013.01); G01R 33/31 (2013.01); G01R 33/42 (2013.01); G01R 33/465 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for generating a hyperpolarized target compound, the system comprising:
a hydrogenation device configured to generate a parahydrogenated solution by mixing a solvent, parahydrogen gas, and a precursor of the target compound, the precursor comprising an unsaturated chemical bond;
a polarization device configured to generate a polarized solution containing the hyperpolarized target compound using the parahydrogenated solution, the polarization device comprising:
(a) a polarization chamber configured to receive the parahydrogenated solution, the polarization chamber including a polarization region having a volume of at least 10 milliliters (mL);
(b) one or more radiofrequency (RF) coils disposed around the polarization region of the polarization chamber; and
(c) a magnetic field source disposed around the polarization region of the polarization chamber and configured to provide a mean magnetic field strength of at most 200 millitesla (mT);
an RF waveform generator coupled to the one or more RF coils of the polarization device, the RF waveform generator configurable to apply a polarization transfer waveform to the one or more RF coils for a predetermined period of time, and wherein the polarization transfer RF waveform comprises at least one of:
a frequency that is substantially constant during the period of time,
a frequency that varies substantially linearly during the period of time,
an amplitude that is substantially constant during the period of time, or
an amplitude that varies substantially linearly over the period of time; and
a purification system configured to separate a purified fraction from the polarized solution.