US 12,216,129 B2
Human antibody having high affinity to human IL-4 receptor alpha
Yong Sung Kim, Suwon-si (KR); Hae-Sim Park, Seoul (KR); Jung Eun Kim, Seoul (KR); and Keunok Jung, Suwon-si (KR)
Assigned to AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Suwon-si (KR)
Appl. No. 17/292,050
Filed by AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Suwon-si (KR)
PCT Filed Nov. 7, 2019, PCT No. PCT/KR2019/015083
§ 371(c)(1), (2) Date May 7, 2021,
PCT Pub. No. WO2020/096381, PCT Pub. Date May 14, 2020.
Claims priority of application No. 10-2018-0137199 (KR), filed on Nov. 9, 2018.
Prior Publication US 2021/0403580 A1, Dec. 30, 2021
Int. Cl. A61K 47/68 (2017.01); A61P 29/00 (2006.01); C07K 16/28 (2006.01); G01N 33/68 (2006.01)
CPC G01N 33/6869 (2013.01) [A61K 47/6845 (2017.08); A61P 29/00 (2018.01); C07K 16/2866 (2013.01); G01N 33/6893 (2013.01); G01N 2333/7155 (2013.01); G01N 2800/24 (2013.01)] 8 Claims
 
1. An isolated antibody or antigen-binding fragment thereof binding to human interleukin-4 receptor alpha (hIL-4Rα) comprising:
a heavy-chain complementarity-determining region (CDR) 1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 14, a heavy-chain CDR3 of SEQ ID NO: 23, a light-chain CDR1 of SEQ ID NO: 43, a light-chain CDR2 SEQ ID NO: 53; and a light-chain CDR3 of SEQ ID NO: 61;
a heavy-chain CDR1 of SEQ ID NO: 12, a heavy-chain CDR2 of SEQ ID NO: 15, a heavy-chain CDR3 of SEQ ID NO: 24, a light-chain CDR1 of SEQ ID NO: 44, a light-chain CDR2 SEQ ID NO: 54; and a light-chain CDR3 of SEQ ID NO: 62;
a heavy-chain CDR1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 16, a heavy-chain CDR3 of SEQ ID NO: 25, a light-chain CDR1 of SEQ ID NO: 45, a light-chain CDR2 SEQ ID NO: 55; and a light-chain CDR3 of SEQ ID NO: 63;
a heavy-chain CDR1 of SEQ ID NO: 13, a heavy-chain CDR2 of SEQ ID NO: 17, a heavy-chain CDR3 of SEQ ID NO: 26, a light-chain CDR1 of SEQ ID NO: 46, a light-chain CDR2 SEQ ID NO: 56; and a light-chain CDR3 of SEQ ID NO: 64;
a heavy-chain CDR1 of SEQ ID NO: 11, a heavy-chain CDR2 of SEQ ID NO: 18, a heavy-chain CDR3 of SEQ ID NO: 27, a light-chain CDR1 of SEQ ID NO: 47, a light-chain CDR2 SEQ ID NO: 57; and a light-chain CDR3 of SEQ ID NO: 65;
a heavy-chain CDR1 of SEQ ID NO: 11, a heavy-chain CDR2 of SEQ ID NO: 19, a heavy-chain CDR3 of SEQ ID NO: 28, a light-chain CDR1 of SEQ ID NO: 48, a light-chain CDR2 SEQ ID NO: 53; and a light-chain CDR3 of SEQ ID NO: 65;
a heavy-chain CDR1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 20, a heavy-chain CDR3 of SEQ ID NO: 29, a light-chain CDR1 of SEQ ID NO: 49, a light-chain CDR2 SEQ ID NO: 58; and a light-chain CDR3 of SEQ ID NO: 66;
a heavy-chain CDR1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 21, a heavy-chain CDR3 of SEQ ID NO: 30, a light-chain CDR1 of SEQ ID NO: 50, a light-chain CDR2 SEQ ID NO: 59; and a light-chain CDR3 of SEQ ID NO: 67;
a heavy-chain CDR1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 22, a heavy-chain CDR3 of SEQ ID NO: 31, a light-chain CDR1 of SEQ ID NO: 51, a light-chain CDR2 SEQ ID NO: 55; and a light-chain CDR3 of SEQ ID NO: 65;
a heavy-chain CDR1 of SEQ ID NO: 11, a heavy-chain CDR2 of SEQ ID NO: 14, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 52, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68;
a heavy-chain CDR1 of SEQ ID NO: 11, a heavy-chain CDR2 of SEQ ID NO: 73, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 52, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68;
a heavy-chain CDR1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 74, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 52, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 81;
a heavy-chain CDR1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 75, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 52, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 82;
a heavy-chain CDR1 of SEQ ID NO:11, a heavy-chain CDR2 of SEQ ID NO: 76, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 52, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68;
a heavy-chain CDR1 of SEQ ID NO:84, a heavy-chain CDR2 of SEQ ID NO: 85, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 92, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68;
a heavy-chain CDR1 of SEQ ID NO:84, a heavy-chain CDR2 of SEQ ID NO: 85, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 93, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68;
a heavy-chain CDR1 of SEQ ID NO:84, a heavy-chain CDR2 of SEQ ID NO: 85, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 94, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68;
a heavy-chain CDR1 of SEQ ID NO:84, a heavy-chain CDR2 of SEQ ID NO: 85, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 95, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68;
a heavy-chain CDR1 of SEQ ID NO:84, a heavy-chain CDR2 of SEQ ID NO: 85, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 96, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68; or
a heavy-chain CDR1 of SEQ ID NO:84, a heavy-chain CDR2 of SEQ ID NO: 85, a heavy-chain CDR3 of SEQ ID NO: 32, a light-chain CDR1 of SEQ ID NO: 97, a light-chain CDR2 SEQ ID NO: 60; and a light-chain CDR3 of SEQ ID NO: 68.