US 12,216,098 B2
Apparatus for processing a liquid comprising a target substance
Charles Heise, Billingham (GB); Jonathan Haigh, Billingham (GB); Tibor Nagy, Billingham (GB); James Pullen, Billingham (GB); and Andrew Topping, Billingham (GB)
Assigned to Fujifilm Diosynth Biotechnologies UK Limited, Billingham (GB)
Appl. No. 16/969,690
Filed by Fujifilm Diosynth Biotechnologies UK Limited, Billingham (GB)
PCT Filed Feb. 11, 2019, PCT No. PCT/GB2019/050351
§ 371(c)(1), (2) Date Aug. 13, 2020,
PCT Pub. No. WO2019/158906, PCT Pub. Date Aug. 22, 2019.
Claims priority of application No. 1802593 (GB), filed on Feb. 16, 2018.
Prior Publication US 2021/0033574 A1, Feb. 4, 2021
Int. Cl. G01N 30/46 (2006.01); C07K 1/34 (2006.01); C12N 15/10 (2006.01); G01N 30/34 (2006.01)
CPC G01N 30/462 (2013.01) [C07K 1/34 (2013.01); C12N 15/1017 (2013.01); G01N 30/34 (2013.01)] 8 Claims
OG exemplary drawing
 
1. An apparatus for processing a liquid comprising a target substance, said apparatus including at least a first means for carrying out a unit operation comprising:
(i) at least two feed liquids being in fluid connection with inlets of a multiple inlet flow-controller comprising two or more variable flow inlet valves for dosing the at least two feed liquids, the multiple inlet flow-controller also comprising an outlet upstream of a first processing device;
(ii) a feed for a liquid feedstock comprising the target substance in fluid connection with the outlet from the multiple inlet flow-controller thereby to enable combination of the feed for a liquid comprising the target substance with mixed bioprocessing liquids to produce a device feed upstream of the first processing device;
(iii) the first processing device for achieving a processing operation comprising a device inlet and a device outlet, the device inlet being in fluid connection with the device feed and producing a first processed liquid feed exiting the first processing device via the device outlet; and
(iv) a means for imparting flow of the at least two feed liquids through the multiple inlet flow controller and the feed for a liquid feedstock comprising the target substance through the first processing device via the device inlet;
the apparatus further comprising a second means for carrying out a unit operation comprising a second processing device, wherein the second means for carrying out a unit operation is connected in series to receive the first processed liquid feed from the first means for carrying out a unit operation, and
wherein the first processing device carries out a different processing function from the second processing device.