US 12,216,080 B2
Systems and methods for electrophoretic separation and analysis of analytes
Joshua I. Molho, Oakland, CA (US); Kelly Gardner, Berkeley, CA (US); Danh C. Tran, Hayward, CA (US); Eric Jabart, Berkeley, CA (US); David Nilson, Walnut Creek, CA (US); Yuri Kouchnir, Sunnyvale, CA (US); Michael Huston, San Jose, CA (US); Colin B. Kennedy, Greenbrae, CA (US); and David John Roach, Los Gatos, CA (US)
Assigned to ProteinSimple, San Jose, CA (US)
Filed by ProteinSimple, San Jose, CA (US)
Filed on Dec. 23, 2021, as Appl. No. 17/560,837.
Application 17/560,837 is a continuation of application No. 15/160,636, filed on May 20, 2016, granted, now 11,237,131.
Claims priority of provisional application 62/164,495, filed on May 20, 2015.
Prior Publication US 2022/0260525 A1, Aug. 18, 2022
Int. Cl. G01N 27/453 (2006.01); G01N 27/447 (2006.01)
CPC G01N 27/44782 (2013.01) [G01N 27/44704 (2013.01); G01N 27/44726 (2013.01); G01N 27/44739 (2013.01); G01N 27/44752 (2013.01); G01N 27/44756 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A system for assaying a biological sample for a presence of a target analyte, the system comprising:
an assaying device having a housing, the assaying device comprising:
a receptacle disposed in the housing and configured to accept an electrophoresis cell, the electrophoresis cell having a recess area configured to accept a chip including a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated, the chip configured to accept the biological sample,
a source of activation energy configured to supply activation energy to activate the activatable functional groups, and
a source of solution configured to provide a flow of a solution from the source of solution to the chip when the electrophoresis cell is within the receptacle; and
a computer controller operably coupled to the source of activation energy, the computer controller operable to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.