US 12,216,079 B2
Sensor circuit for controlling, detecting, and measuring a molecular complex
Kevin Deierling, Pescadero, CA (US); Roger J. A. Chen, Saratoga, CA (US); and David J. Fullagar, Los Gatos, CA (US)
Assigned to Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed by Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed on Feb. 18, 2022, as Appl. No. 17/651,766.
Application 17/651,766 is a continuation of application No. 16/172,488, filed on Oct. 26, 2018, granted, now 11,275,052.
Application 16/172,488 is a continuation of application No. 14/977,312, filed on Dec. 21, 2015, granted, now 10,724,987, issued on Jul. 28, 2020.
Application 14/977,312 is a continuation of application No. 14/591,690, filed on Jan. 7, 2015, granted, now 9,290,805, issued on Mar. 22, 2016.
Application 14/591,690 is a continuation of application No. 13/777,879, filed on Feb. 26, 2013, granted, now 8,986,629, issued on Mar. 24, 2015.
Claims priority of provisional application 61/603,782, filed on Feb. 27, 2012.
Prior Publication US 2022/0170884 A1, Jun. 2, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/447 (2006.01); C12Q 1/6869 (2018.01); C12Q 1/6874 (2018.01); G01N 33/487 (2006.01)
CPC G01N 27/4473 (2013.01) [C12Q 1/6869 (2013.01); C12Q 1/6874 (2013.01); G01N 27/44782 (2013.01); G01N 27/44791 (2013.01); G01N 33/48721 (2013.01); Y10T 436/11 (2015.01)] 20 Claims
OG exemplary drawing
 
1. A device, the device comprising:
a plurality of measurement cells, each measurement cell including a cell electrode above which a nanopore is formed, the cell electrode configurable to apply a distinct potential that is independent from cell electrodes in other measurement cells, the plurality of measurement cells comprising a bank of M×N measurement cells, wherein M refers to a number rows and N refers to a number of columns in the bank of measurement cells; and
a single common electrode configured to be in electrical communication with each cell electrode of the plurality of measurement cells, the single common electrode configured to apply a common potential to a liquid on one side of the nanopores formed above the cell electrodes in the plurality of measurement cells, wherein the common potential is common to all of the measurement cells, wherein a potential across the nanopore in the measurement cell is a difference between the distinct potential applied by the cell electrode of the measurement cell and the common potential applied by the single common electrode.