US 12,216,061 B2
Method for determining a parameter dependent on the concentration of at least one analyte in a sample liquid
Daniel Schweitzer, Remshalden (DE); Ulrich Kathe, Ludwigsburg (DE); and Michael Ingelmann, Vaihingen/Enz (DE)
Assigned to Endress+Hauser Conducta GmbH+Co. KG, Gerlingen (DE)
Filed by Endress+Hauser Conducta GmbH+Co. KG, Gerlingen (DE)
Filed on Dec. 21, 2020, as Appl. No. 17/128,988.
Claims priority of application No. 10 2019 135 489.7 (DE), filed on Dec. 20, 2019.
Prior Publication US 2021/0190700 A1, Jun. 24, 2021
Int. Cl. G01N 21/79 (2006.01); G01N 21/80 (2006.01); G01N 31/16 (2006.01); G01N 33/18 (2006.01)
CPC G01N 21/79 (2013.01) [G01N 21/80 (2013.01); G01N 31/16 (2013.01); G01N 33/1806 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A quantitative titration method for determining a parameter dependent on the concentration of at least one analyte in a sample liquid, comprising:
presenting a sample of the sample liquid;
preparing a solution to be titrated from the sample, wherein the preparation comprises at least:
forming a reaction mixture by adding a volume of a first solution to the sample, wherein the first solution contains a first substance acting as a reaction partner for the at least one analyte, wherein the reaction partner enters into a chemical reaction with the at least one analyte, forming a reaction product of the at least one analyte, wherein the volume of the first solution is adjusted on the basis of measured values of a physical or chemical measurand which are detected during the addition of the first solution in the reaction mixture and whose value depends on the concentration of the at least one analyte or of the first substance in the reaction mixture;
subsequently performing a titration of the solution to be titrated from which a quantity of the first substance present in the reaction mixture after addition of the volume of the first solution is determinable; and
ascertaining a value of the parameter using the titration;
wherein during the addition of the first solution to the sample, the measured values of the physical or chemical measurand are compared with a reference value, and wherein during the addition of the first solution, time periods within which the measured values lie above the reference value or time periods within which the measured values lie below the reference value are detected and added.