	US 12,215,361 B2
	Compositions and methods for making epigenetic modifications
Edwin Neumann, Somerville, MA (US); Tessa Bertozzi, Cambridge, MA (US); and Jonathan Weissman, Cambridge, MA (US)
Assigned to WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, Cambridge, MA (US)
Filed by Whitehead Institute for Biomedical Research, Cambridge, MA (US)
Filed on Feb. 16, 2024, as Appl. No. 18/444,590.
Claims priority of provisional application 63/520,594, filed on Aug. 18, 2023.
Claims priority of provisional application 63/485,860, filed on Feb. 17, 2023.
Prior Publication US 2024/0279623 A1, Aug. 22, 2024
Int. Cl. C12N 9/10 (2006.01); A61K 38/46 (2006.01); C12N 9/22 (2006.01); C12N 15/86 (2006.01)

CPC C12N 9/1007 (2013.01) [A61K 38/465 (2013.01); C12N 9/22 (2013.01); C12N 15/86 (2013.01); C12Y 201/01037 (2013.01); C07K 2319/80 (2013.01); C12N 2750/14143 (2013.01)]

30 Claims

1. A fusion protein comprising a H3K4me0, a DNMT3 methyltransferase-binding domain, and a DNA-binding domain.