US 12,215,328 B2
Plant-produced chimaeric orbivirus VLPs
Albertha René Van Zyl, Wynberg (ZA); Ann Elizabeth Meyers, Plumstead (ZA); Daria Anna Rutkowska, Centurion (ZA); Edward Peter Rybicki, Cape Town (ZA); Hester Catharina Stark, Irene (ZA); Martha Magaretha O'Kennedy, Pretoria (ZA); and Nobalanda Betty Mokoena, Montana (ZA)
Assigned to CSIR, (ZA); ONDERSTEPOORT BILOGICAL PRODUCTS SOC LTD, (ZA); and UNIVERSITY OF CAPE TOWN, (ZA)
Filed by CSIR, Pretoria (ZA); UNIVERSITY OF CAPE TOWN, Cape Town (ZA); and ONDERSTEPOORT BIOLOGICAL PRODUCTS SOC LTD, Pretoria (ZA)
Filed on Jun. 1, 2021, as Appl. No. 17/335,404.
Application 17/335,404 is a division of application No. 16/095,264, granted, now 11,053,509, previously published as PCT/IB2017/052236, filed on Apr. 19, 2017.
Claims priority of application No. 2016/02705 (ZA), filed on Apr. 19, 2016.
Prior Publication US 2021/0388366 A1, Dec. 16, 2021
Int. Cl. C12N 15/82 (2006.01); A61K 35/76 (2015.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61P 31/14 (2006.01)
CPC C12N 15/8205 (2013.01) [A61K 35/76 (2013.01); A61K 39/12 (2013.01); A61P 31/14 (2018.01); C12N 15/8258 (2013.01); A61K 2039/5258 (2013.01); C12N 2720/12134 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A chimaeric African Horse Sickness Virus (AHSV) virus-like particle (VLP) comprising VP2, VP3, VP5 and VP7 structural proteins, wherein the VP3 and VP7 structural proteins are selected from a first AHSV serotype and at least one of the VP2, and VP5 structural proteins is selected from a second AHSV serotype.