US 12,215,174 B2
Compositions of hydroxypropyl-β-cyclodextrin and methods of purifying the same
Steven Pfeiffer, West Hollywood, CA (US); Dustin McMinn, West Hollywood, CA (US); and Gabor Benkovics, Budapest (HU)
Assigned to BEREN THERAPEUTICS P.B.C., West Hollywood, CA (US)
Filed by Beren Therapeutics P.B.C., West Hollywood, CA (US)
Filed on Apr. 11, 2024, as Appl. No. 18/633,063.
Application 18/633,063 is a continuation of application No. 18/384,643, filed on Oct. 27, 2023.
Application 18/384,643 is a continuation of application No. 18/111,237, filed on Feb. 17, 2023, granted, now 11,958,917.
Claims priority of provisional application 63/311,661, filed on Feb. 18, 2022.
Prior Publication US 2024/0270877 A1, Aug. 15, 2024
Int. Cl. C08B 37/16 (2006.01)
CPC C08B 37/0012 (2013.01) 28 Claims
 
1. A composition comprising a mixture of isomerically-purified hydroxypropyl β-cyclodextrin molecules comprising: β-cyclodextrin substituted with seven hydroxypropyl groups (“DS-7”); wherein the mixture further comprises less than 1% by mass β-cyclodextrin substituted with five hydroxypropyl groups (“DS-5”), and wherein the mixture has an average degree of substitution of 6.02-7.98, and wherein the total amount of impurities are measured to be less than or equal to 0.05% by HPLC.