US 12,215,165 B2
Fc variants with altered binding to FcRn
Aaron Keith Chamberlain, San Diego, CA (US); John R. Desjarlais, Pasadena, CA (US); Sher Bahadur Karki, Santa Monica, CA (US); Gregory Alan Lazar, Pacifica, CA (US); Jost Vielmetter, Pasadena, CA (US); and Sean C. Yoder, Santa Monica, CA (US)
Assigned to Xencor, Inc., Pasadena, CA (US)
Filed by Xencor, Inc., Monrovia, CA (US)
Filed on Dec. 13, 2021, as Appl. No. 17/549,706.
Application 17/549,706 is a continuation of application No. 15/710,322, filed on Sep. 20, 2017, granted, now 11,198,739.
Application 15/710,322 is a continuation of application No. 14/930,383, filed on Nov. 2, 2015, granted, now 9,803,023, issued on Oct. 31, 2017.
Application 14/930,383 is a continuation of application No. 11/274,065, filed on Nov. 14, 2005, granted, now 9,200,079, issued on Dec. 1, 2015.
Claims priority of provisional application 60/627,763, filed on Nov. 12, 2004.
Claims priority of provisional application 60/642,886, filed on Jan. 11, 2005.
Claims priority of provisional application 60/649,508, filed on Feb. 2, 2005.
Claims priority of provisional application 60/669,311, filed on Apr. 6, 2005.
Claims priority of provisional application 60/681,607, filed on May 16, 2005.
Claims priority of provisional application 60/690,200, filed on Jun. 13, 2005.
Claims priority of provisional application 60/696,609, filed on Jul. 5, 2005.
Claims priority of provisional application 60/703,018, filed on Jul. 27, 2005.
Claims priority of provisional application 60/726,453, filed on Oct. 12, 2005.
Claims priority of provisional application 60/662,468, filed on Mar. 15, 2005.
Prior Publication US 2022/0112307 A1, Apr. 14, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/00 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C12P 21/08 (2006.01)
CPC C07K 16/32 (2013.01) [C07K 16/2878 (2013.01); C07K 16/2893 (2013.01); C07K 2317/24 (2013.01); C07K 2317/52 (2013.01); C07K 2317/526 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)] 6 Claims
 
1. A composition comprising an Fc variant of a wildtype human IgG Fc polypeptide, wherein said Fc variant comprises a serine residue at position 434, and wherein numbering is according to EU numbering.