US 12,215,154 B2
Compositions and methods for targeting γδ T cells with chimeric antigen receptors
Aimee S. Payne, Merion Station, PA (US); and Christoph T. Ellebrecht, Philadelphia, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Appl. No. 16/963,047
Filed by THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
PCT Filed Jan. 18, 2019, PCT No. PCT/US2019/014227
§ 371(c)(1), (2) Date Jul. 17, 2020,
PCT Pub. No. WO2019/143961, PCT Pub. Date Jul. 25, 2019.
Claims priority of provisional application 62/619,146, filed on Jan. 19, 2018.
Prior Publication US 2020/0339687 A1, Oct. 29, 2020
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01)
CPC C07K 16/2809 (2013.01) [A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/4632 (2023.05); A61K 39/464412 (2023.05); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); A61K 2239/28 (2023.05); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01)] 22 Claims
 
1. An isolated nucleic acid comprising a nucleic acid sequence encoding an anti-GD TCR CAR comprising the amino acid sequence of SEQ ID NO: 1.