US 12,215,149 B2
Anti-MS4A6A antibodies and methods of use thereof
Philip Kong, San Francisco, CA (US); Herve Rhinn, San Francisco, CA (US); Tina Schwabe, San Francisco, CA (US); Angie Yee, San Francisco, CA (US); and Arnon Rosenthal, Woodside, CA (US)
Assigned to Alector LLC, South San Francisco, CA (US)
Filed by Alector LLC, South San Francisco, CA (US)
Filed on Apr. 18, 2022, as Appl. No. 17/722,624.
Application 17/722,624 is a continuation of application No. 16/965,675, abandoned, previously published as PCT/US2019/016141, filed on Jan. 31, 2019.
Claims priority of provisional application 62/624,578, filed on Jan. 31, 2018.
Claims priority of provisional application 62/646,846, filed on Mar. 22, 2018.
Prior Publication US 2022/0380455 A1, Dec. 1, 2022
Int. Cl. C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61P 25/28 (2006.01); C07K 16/28 (2006.01)
CPC C07K 16/28 (2013.01) [A61P 25/28 (2018.01); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An isolated antibody that binds to human MS4A6A, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein:
(i) the heavy chain variable region comprises
an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 14;
an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 29;
an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 43; and
the light chain variable region comprises:
an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 57;
an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 73; and
an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 84;
or
(ii) the heavy chain variable region comprises:
an HVR-H1 comprising the amino acid sequence of SEQ ID NO: 11;
an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 24;
an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 39; and
the light chain variable region comprises:
an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 53;
an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 68; and
an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 84.