US 12,215,102 B2
Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions
Vijay Gokhale, Tucson, AZ (US); and Teri C. Suzuki, Tucson, AZ (US)
Assigned to REGLAGENE, INC., Tucson, AZ (US)
Filed by Reglagene, Inc., Tucson, AZ (US)
Filed on Feb. 28, 2024, as Appl. No. 18/590,806.
Claims priority of provisional application 63/555,767, filed on Feb. 20, 2024.
Claims priority of provisional application 63/591,709, filed on Oct. 19, 2023.
Claims priority of provisional application 63/448,964, filed on Feb. 28, 2023.
Prior Publication US 2024/0327398 A1, Oct. 3, 2024
Int. Cl. C07D 417/14 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61P 35/00 (2006.01); C07D 417/12 (2006.01)
CPC C07D 417/14 (2013.01) [A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61P 35/00 (2018.01); C07D 417/12 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A compound according to formula (I-D):

OG Complex Work Unit Chemistry
wherein R5 is selected from:

OG Complex Work Unit Chemistry
 and
R6 is an aryl or a heteroaryl, wherein the aryl and the heteroaryl are each independently unsubstituted or are each independently substituted with one or more of an alkyl, alkenyl, alkynyl, alkoxyl, alkylsulfo, alkylamino, halogen, thiol, hydroxyl, nitro, cyano, cycloalkyl, heterocyclyl, heterocyclic alkyl, aryl, heteroaryl, cycloalkoxyl, heterocyclic alkoxyl, cycloalkylthio, or heterocyclic alkylthio.