US 12,215,093 B2
Bicyclic carboxamides and methods of use thereof
Yalda Bravo, San Diego, CA (US); Austin Chih-Yu Chen, San Marcos, CA (US); Jinyue Ding, Burnaby (CA); Robert Gomez, North Vancouver (CA); Heather Lam, Scarborough (CA); Joe Fred Nagamizo, San Diego, CA (US); Renata Marcella Oballa, Coquitlam (CA); David Andrew Powell, Vancouver (CA); and Tao Sheng, Coquitlam (CA)
Assigned to TEMPEST THERAPEUTICS, INC., Brisbane, CA (US)
Filed by Tempest Therapeutics, Inc., Brisbane, CA (US)
Filed on Sep. 14, 2023, as Appl. No. 18/467,022.
Application 18/467,022 is a continuation of application No. 17/847,811, filed on Jun. 23, 2022, granted, now 11,795,156.
Application 17/847,811 is a continuation of application No. 17/070,554, filed on Oct. 14, 2020, granted, now 11,472,789, issued on Oct. 18, 2022.
Application 17/070,554 is a continuation of application No. 16/387,294, filed on Apr. 17, 2019, granted, now 10,968,201, issued on Apr. 6, 2021.
Claims priority of provisional application 62/746,843, filed on Oct. 17, 2018.
Claims priority of provisional application 62/659,068, filed on Apr. 17, 2018.
Prior Publication US 2024/0150316 A1, May 9, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 231/56 (2006.01); C07D 209/42 (2006.01); C07D 401/10 (2006.01); C07D 403/10 (2006.01); C07D 405/12 (2006.01); C07D 417/10 (2006.01); C07D 471/04 (2006.01)
CPC C07D 401/10 (2013.01) [C07D 209/42 (2013.01); C07D 231/56 (2013.01); C07D 403/10 (2013.01); C07D 405/12 (2013.01); C07D 417/10 (2013.01); C07D 471/04 (2013.01)] 18 Claims
 
1. A method for the treatment of an EP4-mediated cancer in a patient comprising administering to the patient a compound that is selected from the group consisting of:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.