US 12,215,069 B2
Sirtuin modulating compounds and applications thereof
Célina Reverdy, Chilly Mazarin (FR); Gaetan Gitton, Mt. Laurel, NJ (US); Xiangying Guan, Mt. Laurel, NJ (US); Indranil Adhya, Mt. Laurel, NJ (US); Rama Krishna Dumpati, Mt. Laurel, NJ (US); Samir Roy, Mt. Laurel, NJ (US); Santu Chall, Mt. Laurel, NJ (US); Anisha Ghosh, Mt. Laurel, NJ (US); Gauthier Errasti, Orsay (FR); Thomas Delacroix, Mennecy (FR); and Raj Chakrabarti, Moorestown, NJ (US)
Assigned to CODAGEN BIOSCIENCES, INC., Mt. Laurel, NJ (US)
Filed by Codagen Biosciences, Inc., Mt. Laurel, NJ (US)
Filed on Jan. 24, 2024, as Appl. No. 18/421,117.
Application 18/421,117 is a division of application No. 18/090,953, filed on Dec. 29, 2022, granted, now 12,012,370.
Prior Publication US 2024/0228432 A1, Jul. 11, 2024
Int. Cl. C07C 235/40 (2006.01); C07D 209/82 (2006.01); C07D 213/56 (2006.01); C07D 215/50 (2006.01); C07D 223/28 (2006.01); C07D 295/155 (2006.01); C07D 333/80 (2006.01)
CPC C07C 235/40 (2013.01) [C07D 209/82 (2013.01); C07D 213/56 (2013.01); C07D 215/50 (2013.01); C07D 223/28 (2013.01); C07D 295/155 (2013.01); C07D 333/80 (2013.01)] 5 Claims
 
1. A sirtuin inhibiting compound and/or salt thereof is of Formula I:

OG Complex Work Unit Chemistry
wherein Ar1 is aryl or heteroaryl, R1-R7 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, —C(O)R8, alkoxy, halo, nitryl (—NO2), and hydroxy, wherein the Ar1, alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl are optionally substituted with one or more substituents selected from the group consisting of (C1-C10)-alkyl, (C1-C10)-alkenyl, alkoxy, halo, amine, and hydroxy; and wherein R8 is selected from the group consisting of alkyl, alkenyl, and NR9R10, wherein R9 and R10 are independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and wherein m and n are integers each having a value independently selected from 0 to 10.