US 12,215,067 B2
Chemical compounds targeting the eye and use thereof in the treatment of eye diseases
Laurence Dinan, Dorchester (GB); René Lafont, Paris (FR); Pierre Dilda, Paris (FR); Serge Camelo, La Plaine Saint-Denis (FR); Valérie Fontaine, Savigny le Temple (FR); Christine Balducci, Saint Germain les Arpajon (FR); Elodie Monteiro, Saint Maur des Fossés (FR); Louis Guibout, Asnières-sur-Seine (FR); Mathilde Latil, Paris (FR); José-Alain Sahel, Paris (FR); and Stanislas Veillet, Savigny sur Orge (FR)
Assigned to BIOPHYTIS, Paris (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), Paris (FR); and SORBONNE UNIVERSITE, Paris (FR)
Appl. No. 17/788,534
Filed by BIOPHYTIS, Paris (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), Paris (FR); and SORBONNE UNIVERSITE, Paris (FR)
PCT Filed Dec. 22, 2020, PCT No. PCT/FR2020/052605
§ 371(c)(1), (2) Date Jun. 23, 2022,
PCT Pub. No. WO2021/130451, PCT Pub. Date Jul. 1, 2021.
Claims priority of application No. 1915598 (FR), filed on Dec. 26, 2019.
Prior Publication US 2023/0089459 A1, Mar. 23, 2023
Int. Cl. C07C 211/21 (2006.01); A61P 27/02 (2006.01); C07D 207/06 (2006.01); C07D 211/32 (2006.01); C07D 265/30 (2006.01); C07D 273/06 (2006.01); C07D 307/36 (2006.01)
CPC C07C 211/21 (2013.01) [A61P 27/02 (2018.01); C07D 207/06 (2013.01); C07D 211/32 (2013.01); C07D 265/30 (2013.01); C07D 273/06 (2013.01); C07D 307/36 (2013.01)] 20 Claims
 
1. Chemical compound having the following general formula (I):

OG Complex Work Unit Chemistry
where COR is a secondary or tertiary amide, such that —R is chosen from:
M; —NH—(CH2)n-M and —NH—(CH2)n—C(CH3)(CH3)-M, -M being chosen from
a)

OG Complex Work Unit Chemistry
wherein,
R1 is chosen from an oxygen atom, a sulfur atom, a >CH2, >CH—O—(CH2)n—CH3, >CH—(CH2)n—O—(CH2)n—CH3, >CH—(CH2)n—OH, >CH—COOH, >C(OH)phenyl or >NH group;
R3 is chosen from a hydrogen atom, a C1-C6 alkyl, —OH or C1-C6 —O-alkyl group;
R4 is chosen from a hydrogen atom, a C1-C6 alkyl, —OH or C1-C6 —O-alkyl group;
n is an integer comprised between 0 and 6;
—NH—(CH2)n—W, W being a hydrogen atom, or a —OH group, a —O—(CH2)n—CH3 group, or a group chosen from
i)

OG Complex Work Unit Chemistry
wherein,
R1 is chosen from an oxygen atom, a sulfur atom, a >CH2, >CH—O—(CH2)n—CH3, >CH—(CH2)n—OH, >CH—COOH, >C(OH)phenyl or >NH group;
R3 is chosen from a hydrogen atom, a C1-C6 alkyl, —OH or C1-C6 —O-alkyl group;
R4 is chosen from a hydrogen atom, a C1-C6 alkyl, —OH or C1-C6 —O-alkyl group;
R5 is chosen from a —CH3, —OH, —O—(CH2)n—CH3, —(CH2)n—OH or —COOH group;
n is an integer comprised between 0 and 6;
as well as the pharmaceutically acceptable salts of said chemical compound.