US 12,214,329 B2
Nicotinamide dummy template surface molecularly imprinted polymer and preparation method and application thereof
Hongxin Wang, Wuxi (CN); Jingyu Chen, Wuxi (CN); Shijia Wu, Wuxi (CN); Xinlin Wei, Wuxi (CN); Xin Huang, Wuxi (CN); and Li Wang, Wuxi (CN)
Assigned to Jiangnan University, Wuxi (CN)
Filed by Jiangnan University, Wuxi (CN)
Filed on Dec. 15, 2021, as Appl. No. 17/551,338.
Application 17/551,338 is a continuation of application No. PCT/CN2020/105396, filed on Jul. 29, 2020.
Claims priority of application No. 201911188009.9 (CN), filed on Nov. 28, 2019.
Prior Publication US 2022/0105491 A1, Apr. 7, 2022
Int. Cl. B01J 20/26 (2006.01); A23F 3/20 (2006.01); B01D 15/22 (2006.01); B01J 20/30 (2006.01); C07C 37/82 (2006.01); C07C 231/24 (2006.01); C08F 292/00 (2006.01)
CPC B01J 20/268 (2013.01) [A23F 3/205 (2013.01); B01D 15/22 (2013.01); B01J 20/3085 (2013.01); C07C 37/82 (2013.01); C07C 231/24 (2013.01); C08F 292/00 (2013.01); B01J 2220/46 (2013.01); B01J 2220/4806 (2013.01); B01J 2220/4812 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A method of using a nicotinamide dummy template surface molecularly imprinted polymer (DMIP), comprising preparing the DMIP, and adding the DMIP in a tea extract aqueous solution and removing imidacloprid and acetamiprid from the tea extract aqueous solution, wherein a preparation method of the nicotinamide dummy template surface molecularly imprinted polymer comprises the following steps:
A1. preparation of a modified silica gel carrier
soaking granular silica gel in hydrochloric acid for treatment, filtering and washing the silica gel to neutral and drying the silica gel; in g/mL, mixing the dried silica gel with toluene in a mass-volume ratio of 1:40-1:8; adding 3-aminopropyltriethoxysilane (APTS) and pyridine dropwise, and at a reaction temperature of 363-383 K in a nitrogen atmosphere, performing refluxing for 20-30 h; after washing the obtained mixture with toluene, acetone, ether and methanol, performing vacuum drying to prepare amino-modified silica gel;
in g/mL, mixing the amino-modified silica gel with toluene in a mass-volume ratio of 1:40-1:8; adding acryloyl chloride in a nitrogen atmosphere, adding triethylamine dropwise after magnetic stirring, and performing stirring at room temperature for reacting for 20-30 h; and after washing the obtained mixture with toluene, acetone, ether and methanol, performing vacuum drying to prepare acyl-modified silica gel; and
A2. preparation of a dummy template surface molecularly imprinted polymer in g/mL, dissolving nicotinamide in a methanol aqueous solution at a mass-volume ratio of 1:1-3:1; adding the acyl-modified silica gel and methacrylic acid (MAA), and after ultrasonic dispersion, reacting for 2-6 h in the dark, wherein a mass ratio of the nicotinamide to the acyl-modified silica gel is 5:6-5:3; after the reaction, adding ethylene glycol dimethacrylate (EGDMA) and azobisisobutyronitrile (AIBN) in a nitrogen atmosphere, and performing sealed reaction at 323-343 K in a water bath for 20-28 h; and removing a template by Soxhlet extraction, and performing washing and drying to prepare the dummy template surface molecularly imprinted polymer.